Health And Medical Education Department Tender

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Health And Medical Education Department Tender

Goods

Laboratory Equipment and Services

Eprocure

Baramulla, Jammu & Kashmir

Opening Date8 Aug 2023

Closing Date8 Sep 2023

Tender AmountRefer Documents

Email

Download

Costs

EMD
₹ 30,000
Document Cost
₹ 1,000
Tender Fee
Refer Documents

Description

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Contact

Tender Id
2023_HME_222402_1
Bid Award Id
View
Tender No
16 GMCB OF 2023
Tender Authority
Health And Medical Education Department View
Purchaser Address
-
Website
http://http://jkhealth.org/new2017/

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Documents

Tender Notice-21.2 MBTendernotice_1.pdf

Tender Document

Tender Notice-11.2 MBBIOCHEMISTRYCHARTS...BIOCHEMISTRYCHARTS16gmcbbiochemistry.pdf

eNIT

BOQ-1383.5 kBBOQ_624261.xls

BOQ

Corrigendum-1335.0 kBdatecorrigendum16g...datecorrigendum16gmcb2023.pdf

Document-2677.5 kBdateextension16gmc...dateextension16gmcb20232.pdf

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BOQ Items

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Acids and bases - Acids and bases, pH values in the body, Buffers.

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Redox Processes - Redox reactions, Reducing equivalents, Biological.

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Overview - Carbohydrates overview, Monosaccharides structure.

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Chemistry of sugar - Reactions of the monosaccharides, Polarimetry, Mutarotation.

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Monosaccharides and Disaccharides - Important monosaccharides.

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Polysaccharides overview - Polysaccharides structure, Important Polysaccharides.

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Plant Polysaccharides - Cellulose, Starch.

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Glycosaminoglycans and Glycoproteins - Hyaluronic acid, Oligosaccharide

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Fatty acid and fats - Carboxylic acids , Structure of fats

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Phospholipids and Glycolipids - Structure of fats, Phospholipids and Glycolipids

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Steroid structure - Steroid building blocks, 3D structure, Thin-layer Chromatography

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Steroid : overview - Sterols, Bile acids, Steroid hormones

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Chemistry and properties - Amino acids: functions, Optical activity, Dissociation curve of histidine B27

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Proteinogenic amino acids - The proteinogenic amino acids,

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Non-Proteinogenic amino acids - Rare amino acids, Post-translational Protein modification, Biogenic amines

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Overview - Proteins

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Peptide bonds - Peptide bonds, Resonance, Peptide nomenclature, Conformation space of the peptide chain

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Secondary structures - Helix, Collagen Helix, Pleated-sheet structures, B - Turns

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Protein folding - Folding and denaturation of ribonuclease, Energetics of protein folding

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Molecule models : Insulin - Structure of insulin, Insulin (monomer)

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Isolation and analysis of proteins - Salt precipitation, Dialysis, Gel filtration, SDS gel electrophoresis

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RNA- Ribonucleic acids (RNAs), Transfer RNA (tRNA)

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DNA- DNA: structure, Coding of genetic information

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Molecular model: DNA and RNA- DNA: Conformation, RNA

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Enzyme Kinetics 1 - Michaelis Menten kinetics, Isosteric and allosteric enzymes

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Enzyme Kinetics 11- pH and temperature dependency of enzyme activity, Substrate specificity, Bisubstrate kinetics

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Inhibitors - Types of inhibitor, Kinetics of inhibition

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Lactate dehydrogenase : structure - Lactate dehydrogenase: structure, Isoenzymes

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Lactate dehydrogenase: mechanism - A. Lactate dehydrogenase : catalytic cycle

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Enzymatic analysis - Principle of spectrophotometry, Assay of lactate Dehydrogenase activity , Enzymatic determination of glucose

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Intermediary metabolism - Intermediary metabolism : overview

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Allosteric regulation - Aspartate carbamoyl transferase : reaction, Kinetics, R and T conformation, Structure of a dimer

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Transcription Control - Functions of regulatory proteins, Lactose operon

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Hormonal Control - Principles of hormone action, Hormonal regulation of glucose metabolism in the liver

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Tricarboxylic acid cycle : reactions - Tricarboxylic acid cycle

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Tricarboxylic acid cycle : Functions - Tricarboxylic acid cycle: functions

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Respiratory Chain - Components of the respiratory chain, Organization

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ATP synthesis - Redox systems of the respiratory chain, ATP synthase

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Regulation - Respiratory control, Uncouplers

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Glycogen metabolism - Glycogen metabolism, Glycogen balance

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Regulation - Regulation of carbohydrate metabolism, Fructose 2, 6-bisphosphate

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Diabetes mellitus - Insulin biosynthesis, Effects of insulin deficiency

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Fatty acid synthesis - Fatty acid synthase

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Protein Metabolism: over view - Protein metabolism : overview

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Urea Cycle - Urea cycle

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Nucleotide degradation - Degradation of nucleotides Hyperuricemia (gout)

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Purine and pyrimidine biosynthesis - Components of nucleobases, Pyrimidine and purine synthesis

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Heme bio synthesis - Heme biosynthesis

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Heme degradation - Degradation of heme groups

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Structure of cell - Comparison of prokaryotes and eukaryotes, Structure of an animal cell

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Transport Processes - Permeability of membranes, Passive and active transport, Transport processes

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Transport proteins - Transport mechanisms, Glucose transporter Glut-1, Aquaporin-1, Sarcoplasmic Ca+2 pump

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Ion channels - Voltage-gated Na+ channel, Nicotinic acetylcholine receptor, K+ channel in Streptomyces lividans

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Membrane receptors - Principle of receptor action, Insulin receptor, 7-Helix receptors, T- cell receptor

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Over view - Expression and transmission of genetic information

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Genome - Chromatin, B. Histone

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Replication - Mechanism of DNA polymerases, Replication in E. coli

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Transcription -Transcription and maturation of RNA: overview, Organization of the PEP-CK gene, Process of transcription

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Transcriptional Control - Initiation of transcription, Regulation of PEP-CK transcription

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RNA Maturation - 5' and 3' modification of m RNA, Splicing of hnRNA, Spliceosome

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Amino acid activation - The genetic code, Amino acid activation Asp-tRNA-Ligase (Dimer)

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Translation 1: initiation - Structure of eukaryotic ribosomes, Polysome Initiation of translation in E. Coli

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termination of protein biosynthesis in E. Coli

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Antibiotics - Antibiotics: overview, Intercalators, C. Penicillin as "suicide substrate"

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Mutation and Repair - Mutagenic agents, Effects, Repair mechanisms

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DNA cloning - Restriction endonucleases, DNA cloning

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DNA sequencing - Gene libraries, Sequencing of DNA

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PCR and protein expression - Polymerase chain reaction (PCR), DNA electrophoresis, Over expression of proteins

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Genetic engineering in medicine - DNA fingerprinting, Diagnosis of sickle-cell anemia using RFLP, Evidence of viral DNA using RT-PCR, Gene therapy

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Composition and functions - Functions of the blood, Cellular elements, Blood plasma: composition

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Plasma proteins - Plasma proteins, Electrophoresis

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Lipoproteins - Composition of lipoprotein complexes, Transport functions

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Hemoglobin - Hemoglobin: structure, Hemoglobin: allosteric effects

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Gas transport- Regulation of O2 transport, Hemoglobin and CO2 transport, Hemoglobin and CO2 transport

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Erythrocyte metabolism - Reactive oxygen species, Biological antioxidants, Erythrocyte metabolism

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Iron metabolism - Distribution of iron, Iron metabolism

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Acid-base balance - Hydrogen ion concentration in the blood plasma, Acid-base balance, Buffer systems in the plasma

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Blood clotting - Blood clotting

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Fibrinolysis blood groups - Fibrinolysis, Blood groups: the AB0 system

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Immune response - Simplified scheme of the immune response

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T- cell activation - Antigen receptors, T cell activation

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Complement system - Complement activation

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Antibodies - Domain structure of immunoglobulin G, Classes of immunoglobulins

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Antibodies biosynthesis - Variability of immunoglobulins, Origins of antibody variety, Biosynthesis of a light chain.

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Monoclonal antibodies, immunoassay - Monoclonal antibodies Immunoassay

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Functions - Diagram of a hepatocyte, Functions of the liver, Liver metabolism

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Buffer Function in organ metabolism - Absorptive state, Post absorptive state

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Carbohydrate metabolism – Gluconeogenesis : overview, Fructose and Galactose metabolism

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Lipid metabolism - Lipid metabolism, Biosynthesis of ketone bodies

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Bile acids - Bile acids and bile salts, Metabolism of bile salts

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Biotransformation

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Cytochrome P450 systems - Cytochrome P450 - dependent

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Ethanol metabolism - Blood ethanol level, Ethanol metabolism, Liver damage due to alcohol

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Functions - Functions of the kidneys, Urine formation

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Urine-Urine, Organic constituents, Inorganic constituents

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Function in the acid -base balance - Proton secretion, Ammonia excretion

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Electrolyte and water recycling - Electrolyte and water recycling, Gluconeogenesis

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Renal hormones - Renal hormones, Renin angiotensin system

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Bone and teeth - Bone, Teeth

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Calcium metabolism - Functions of calcium, Bone remodelling, Calcium homeostasis,

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Collagens - Structure of collagens, Biosynthesis

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Extracellular matrix - Extracellular matrix, Fibronectins, Proteoglycans

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Signal transmission in the CNS - Structure of nerve cells

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Neurotransmitters and neurohormones, Synaptic signal transmission

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Resting potential and action potential - Resting potential, Action potential

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Neurotransmitters - Important neurotransmitters, Biosynthesis of the catecholamines

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Receptors for neurotransmitters -Receptors for neurotransmitters, Acetylcholine receptors, Metabolism of ecetylcholine

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Metabolism - Energy metabolism of the brain, Glutamate, glutamine, and GABA

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Organic substances - Energy requirement, Nutrients

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Minerals and trace elements - Minerals

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Lipid- soluble vitamins - Vitamin supply, Lipid-soluble vitamins

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Water- soluble vitamins 1 - Water-soluble vitamins I

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Water- soluble vitamins 11 - Water-soluble vitamins II

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Basics - A. Hormones: overview, A. Hormonal regulation system

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Plasma levels and hormone hierarchy - A. Endocrine, paracrine and autocrine hormone effects, B. Plasma level dynamics, C. Regulatory circuit, D. Hormone hierarchy

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Lipophilic Hormones

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Metabolism of steroid hormones - Biosynthesis of steroid hormones Inactivation of steroid hormones

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Mechanism of action - Mechanism of action of lipophilic hormones Receptors of lipophilic hormones

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Metabolism of Peptide Hormones - Biosynthesis, Degradation and inactivation

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Mechanisms of action - Mechanisms of action, Signal transduction by G proteins

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Second messengers - Cyclic AMP, Inositol 1,4,5- trisphosphate and diacylglycerol, Calcium ions

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Signal cascades - Insulin: signal transduction, Nitrogen monoxide (NO) as a mediator

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Eicosanoids -Eicosanoids

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cytokines - Cytokines, Signal transduction in the cytokines

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Cell cycle - Cell cycle, Control of the cell cycle

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Apoptosis - Cell proliferation and apoptosis, Regulation of apoptosis.

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Oncogenes - Proto-oncogenes: biological role, Oncogene products: biochemical functions

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Tumors - Division behavior of cells, Transformation,

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Cytostatic drugs- Alkylating agents, anthracyclines, Antimetabolites

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VIRUSES - Viruses: examples, Capsid of the rhino virus

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Calvin cycle - Calvin cycle (plant chloroplasts)

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Carbohydrate metabolism - Carbohydrate metabolism, Biosynthesis of fats and membrane lipids

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Membrane liquids

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Synthesis of ketone bodies and steroids - Synthesis of ketone bodies and steroids

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Degradation of fats and phospholipids - Degradation of fats and phospholipids

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Biosynthesis of the essential amino-acids -Degradation of fats and phospholipids

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Biosynthesis of the non-essential amino-acids - Biosynthesis of the non-essential amino acids

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Amino acid degradation I

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Amino acid degradation II

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Ammonia metabolism - Ammonia metabolism

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Biosynthesis of purine nucleotides - Biosynthesis of purine nucleotides

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Biosynthesis of the pyrimidine nucleotides and - Biosynthesis of the pyrimidine nucleotides and C1

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Metabolism nucleotide degradation – Nucleotide degradation

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RENOWNED SCIENTISTS CHARTS CHARTS SHOULD BE OF SIZE 20” ×26”, THICK, LAMINATED ON BOTH SIDES AND ATTACHED WITH PLASTIC STRIPS

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Sanger Fredrick

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Krebs, Sir Hans Adolf

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Lehninger

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Joseph Lister

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Carl Neuberg, Father of Biochemistry

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William Astbury

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Francis Crick.

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Arthur Kornberg

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Peter D. Mitchell

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Kary Mullis

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Rosalind Franklin

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Linus Pauling

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James D. Watson

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