University Of Ottawa Tender

The Preparatory Hplc Will Be Capable Of Purifying Large Amounts Of Crude Mixtures Of Organic Compounds Including Small Molecules, New Drug Species, Carbohydrates, Optical Imaging Probes, Peptides (both Linear And Cyclic Or Stapled), Cannabinoids,fatty Acids And Other Alkyl-derived Compounds. Importantly, The Multidetector Capability Will Allow All Variety Of Compounds To Be Evaluated And For The Identification Of Specific Peaks And/or Elution Times To Be Collected By A Liquid Handling Robot. This Liquid Handling Robot Can Serve As Fraction Collector, Autosampler, And Can Re-inject Collected Fraction Samples To Evaluate Fraction Purity, In Effect Semi-automating Compound Purification. This System Should Be Compatible With Labsolutions Lcgc Workstation Due To Legacy Data Collected With This Software Package Over The Last Decade. The Instrument Should Allow For A Broad Range Of Flow Rates (0.01 To 150 Ml/min), With Syringe Pump Rinsing Between Injections, Operating With High Flow Rate Accuracy And Good Flow Rate Precision. The Hplc Must Be Able To Accommodate Up To 2 G Of Maximum Injection Load On A 25 Cm Long, 50 Mm I.d. Column. The Hplc System Must Be Capable Of Automated Purity Checks Of The Collected Samples. The Liquid Handling System Must Be Capable Of Both Sampling And Fraction Collection, And Fraction Re-analysis Must Be Automated. The Liquid Handler Must Minimize Sample Carryover Between Injections, And The Injection Needle Must Be Able To Detect The Liquid Surface Level To Prevent Any Injection Of Air. Volumes Up To 5 Ml Must Be Able To Be Injected. The System Must Include A Column Oven (with Switch Valve). The Diode Array Detector Must Operate From 190-800 Nm With Minimum 1024 Element Diode. The Detector Must Show Good Linearity With Pressure Tolerance Of 12 Mpa. The Refractive Index Detector Must Have A Dual-temperature Controlled Block So That Baseline Stability Is Reached Within 30 Min Of Power On, And Must Accommodate A Broad Refractive Index Range Up To 150 Ml/min. The Fluorescence Detector Must Be Able To Monitor Two Wavelengths Simultaneously. The Evaporative Light Scattering Detector Must Be Able To Operate At Ambient-80°c, With A Nebulizer/drift Tube That Is Separated And Protected From Fouling. The Environment Where The Equipment Will Be Placed Is A Regular Lab At The University