University Of Dundee Tender

Second-generation Framework For The Provision Of Chemistry Synthesis And Other Chemistry Services Outsourcing With Initial Term Of Two (2) Years With The Option To Extend For Up To 2 X 12 Months, If Required, At The Sole Discretion Of The University And Subject To Ongoing Satisfactory Performance By The Appointed Service Providers. The Services Will Include: 1. Fte Rate For Provision Of Chemistry Support For Medicinal Chemistry Programme(s), Typically Making 50mg Samples Of Compounds For Initial Biological Evaluation. For Actives, Re-synthesis On A Larger Scale May Be Required (typically 0.5g To 5g Scale). The Ability To Carry Out Array Chemistry Is Important; 2.bespoke Piece(s) Of Chemistry E.g. Synthesis Of A Defined List Of Compounds, Typically At <50mg Scale; 3. Scale Up Of Chemistry, Up To 200g; 4.chiral Separation By Crystallization Or Sfc/chiral Hplc On (up To) Gram Scale. 5.synthesis Of Intermediates At 5-100g; For All Of These, A Purity Level Will Be Defined. This Will Depend On The Phase Of The Project, But Typically Is >95% Purity And For Scale Up> 98% Purity With No Impurity >0.5%; 6. Experimental Write-ups, When Requested, Including Compound Characterization By 1h Nmr, 13c Nmr And Lcms Or Uplc/ms For Publications, In-vivo Release, Tech-transfer To Ddu Or Other Cro For Patent Purposes. Cpv: 73110000, 73110000.