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Lc Inlet For The Mass Detector-consisting Of The Following Components Quaternary Pump With A Minimum Of 4 Solvents – To Be Connected And Mixed On The Instrument In Any Configuration At The Same Time Flow In The Minimum Range Of 0.001 – 2,200 Ml/min In Increments Of 0.001 Ml Or Better Flow Accuracy: 0.075% Rsd Or Better Precision Of Mobile Phase Composition: <0.15% Rsd Or Better Total System Delay Volume Should Not Be Greater Than <400 Μl. Dwell Volume Of The System <300 Μl Maximum Volume During Peak Spread (band Spread) Of The System 12 Μl An Autosampler With A Capacity Of A Minimum Of 2 96-well Plate Holders Injection Volume In The Minimum Range: 0.1 – 1000 Μl Temperature For Samples In The Range Of 4°c To 40°c Or Better, In Increments Of 0.1°c Minimum Tandem Quadrupole Ms - Composed Of The Following Components The Mass Tandem Quadrupole Detector Must Have A Compact Design So That It Can Be Placed On A Table (benchtop) Mandatory Atmospheric Pressure Ionization Liquid Chromatography Interface (api) To Include Source And Spray Unit A Minimum Of Two Built-in Tanks For System Tuning And Calibration Automatically Included In The Instrument Control Software. Classic Syringe Pumps And Tuning From Autosampler Vials Are Not Acceptable Ion Source Needle With Appropriate Angle For Optimal Formation Of Fine Droplets In-analyzer Transfer Optics With Double Orthogonal Design To Reduce Source Contamination And Separation Of Ion Clusters Formed Under Atmospheric Pressure And For Ultra-high Resistance To Matrix Effects Easy Removal Of Ion Source And Cone Elements And Desolvation Mechanisms For Cleaning And Maintenance Without Turning Off Instrument Vacuum To Allow Maximum Instrument Uptime The Ion Transfer Interface And Optics In The Analyzer Are Not Subject To Routine Maintenance, Replacement Of Spare Parts Or Cleaning Of Spare Parts Such As Transfer Lines Or Capillaries Positive And Negative Ionization Modes Are Included As Standard Instrument Options And Can Be Used In The Same Injection. Time To Change From Positive To Negative Polarity During One Analysis To Be A Maximum Of 20 Msec Standard Esi/apci Combined Ion Source (esci Or Equivalent) With A Mode Switching Time Of 20 Msec Maximum The Instrument Must Have Two Quadrupole Mass Analyzers, A Collision Cell, And Mass Prefilters To Protect Against Contamination Of The Main Mass Analyzers And Increase Ion Resolution With A Linear Geometric Design. Mandatory Change From Ms To Ms/ms (mrm) Scan Mode Of Operation At Automated Optional Intervals Of Maximum 3 Msec To Allow Validation Of Methods Under Ion Suppression And Matrix Effects. The Scan Option Should Be Enabled By Default In The Software. Adequate Documentation Must Be Submitted To Verify Performance. The Instrument Must Be Able To Work In The Following Acquisition Modes Or Scan Options: • Full Scan Ms And Sim For Both Quadrupoles (q1 And Q2) Multi Reaction Monitoring (mrm) • Precursor Ion Scan • Product Ion Scan • Neutral Loss Scan The Instrument Should Have Built-in Ion Concentration Enhancement Technology In The Mass Analyzer To Achieve Additional Selectivity And Sensitivity For The Following Acquisition And Scan Modes: Full Scan Ms Triggered Product Ion Scan Precursor Ion Scan Triggered Product Ion Scan Constant Neutral Loss Triggered Product Ion Scan Ms Full Scan Q2 And Ms/ms (mrm) Parallel In Tandem Quadrupole Mode Of Operation, The Instrument Must Have A Scan Rate Of At Least 10,000 Da/sec A Suitable At Least One Air-cooled Turbomolecular Pump Included A Pre-vacuum Pump Must Be Supplied To Support The Turbomolecular Pump The Linearity Of The Detector Response For A Specific Component In The Sample Must Be At Least 5 Orders Of Magnitude Relative To The Concentration At The Lod Level Mass Range 5 To 2040 M/z Or Better The Detector Must Be A Photomultiplier To Ensure A Minimum Of 10 Years Of Operation Of The Detector Without The Need For Maintenance Mrm Sensitivity (esi+) With Standard Esi Ion Source - 1 Pg Of Reserpine When I. The Procurement Is Related To A Project And/or Programme Financed By European Union Funds: No