National Institutes Of Health Tender

This Is A Small Business Sources Sought Notice. This Is Not A Solicitation For Proposals, Proposal Abstracts, Or Quotations. the Purpose Of This Notice Is To Obtain Information Regarding: (1) The Availability And Capability Of Qualified Small Business Sources; (2) Whether They Are Small Businesses; Hubzone Small Businesses; Service-disabled, Veteran-owned Small Businesses; 8(a) Small Businesses; Veteran-owned Small Businesses; Woman-owned Small Businesses; Or Small Disadvantaged Businesses; (3) Their Size Classification Relative To The North American Industry Classification System (naics) Code For The Proposed Acquisition. your Responses To The Information Requested Will Assist The Government In Determining The Appropriate Acquisition Method, Including Whether A Set-aside Is Possible. An Organization That Is Not Considered A Small Business Under The Applicable Naics Code Should Not Submit A Response To This Notice. this Notice Is Issued To Help Determine The Availability Of Qualified Companies Technically Capable Of Meeting The Government Requirement And To Determine The Method Of Acquisition.  It Is Not To Be Construed As A Commitment By The Government To Issue A Solicitation Or Ultimately Award A Contract.  Responses Will Not Be Considered As Proposals Or Quotes.  No Award Will Be Made As A Result Of This Notice.  The Government Will Not Be Responsible For Any Costs Incurred By The Respondents To This Notice.  This Notice Is Strictly For Research And Information Purposes Only. background:  Microstructural Mri Techniques Are Unique Among Neuroimaging Modalities Because They Probe Tissue Features At The Micron Scale That Are Invisible Using Other Methods. This Class Of Mri Methods Promises To Address The Unmet Needs For Neuroimaging In Alzheimer’s Disease (ad) And Related Dementias: (1) Early Detection Of Subtle Cellular And Protein Alterations And (2) Delineation Of Comorbid Pathologies. In Particular, Diffusion Mri Is Sensitive To Alterations In Cellularity And Other Microstructural Changes, And Relaxometery Mri Is Sensitive To Chemical Composition And Macromolecular Content. Combining Both Modalities, Multidimensional Mri Is An Emerging Modality That Maximizes Chemical And Microstructural Information By Probing Relaxation And Diffusion Mechanisms Simultaneously. This Approach Is Ideal For Detecting Ad Pathology, Namely Beta-amyloid Plaques And Tau Tangles, As Well As Comorbid Pathologies. In Order To Actualize The Promise Of This Method, A Bridge Must Be Built Between The Pathologic Changes That Define Ad And Detectable Multidimensional Mri Signatures. Investigators In The Laboratory Of Behavioral Neuroscience, Laboratory Of Genetics & Genomics, And The Translational Gerontology Branch Propose Three Research Aims That Apply A “bottom-up'' Approach, Using Radiologic-pathologic Correspondence Findings In Postmortem Human Tissue, And Perform The First Study That Uses This Mri Technology In Conjunction With Histology, Transcriptomics, And Proteomics To Deliver A Clear Understanding Of The Associations Between Specific Cellular And Macromolecular Alterations In Ad And The Mri Responses To Them. purpose And Objectives: Highly Characterized (e.g., Body Mass Index, Neuropathological Examination Of Cardiovascular Conditions, Circle Of Willis Atherosclerosis Score, White Matter Rarefaction Score, Coronary Atherosclerosis Score, Heart Weight, Myocardial Infarct Score, And Clinical Diagnoses) Fixed Human Temporal Lobe Specimens That Include The Hippocampus From Alzheimer’s Disease Patients Were Obtained By Laboratory Of Behavioral Neuroscience (lbn) At The National Institute On Aging (nia) From The Banner Sun Health Research Institute Brain And Body Donation Program (bbdp). The Specimens Were Loaned To The Lbn For Advanced Multidimensional Mri Characterization Through A Material Transfer Agreement. Upon Completion Of The Mri Scans, The Lbn Will Ship The Specimens Back To The Bbdp To Perform Histological Assessment That Is Vital For Radiological-pathological Correlation And The Completion Of The Study. project Requirements: Independently And Not As An Agent Of The Government, The Contractor Shall Furnish All The Necessary Services, Qualified Personnel, Material, Equipment, And Facilities, Not Otherwise Provided By The Government As Needed To Perform The Statement Of Work Attached To This Sources Sought Notice. anticipated Period Of Performance: 4 Months After Contract Award. capability Statement /information Sought. small Business Concerns That Believe They Possess The Capabilities To Provide The Required Services Should Submit Documentation Of Their Ability To Meet Each Of The Project Requirements To The Contracting Officer. The Capability Statement Must Specifically Address Each Of The Project Requirements Separately.  Additionally, The Capability Statement Should Include 1) The Total Number Of Employees, 2) The Professional Qualifications Of Personnel As It Relates To The Requirements Outlined, 3) Any Contractor Gsa Schedule Contracts And/or Other Government-wide Acquisition Contracts (gwacs) By Which All Of The Requirements May Be Met, If Applicable, And 4) Any Other Information Considered Relevant To This Program. Small Businesses Must Also Provide Their Company Name, Unique Entity Id Number From Sam.gov, Physical Address, And Point Of Contact Information. interested Small Businesses Are Required To Identify Their Type Of Business, Applicable North American Industry Classification System (naics) Code, And Size Standards In Accordance With The Small Business Administration. The Government Requests That No Proprietary Or Confidential Business Data Be Submitted In A Response To This Notice. However, Responses That Indicate The Information Therein Is Proprietary Will Be Properly Safeguarded For Government Use Only. Capability Statements Must Include The Name And Telephone Number Of A Point Of Contact Having Authority And Knowledge To Discuss Responses With Government Representatives. Capability Statements In Response To This Market Survey That Do Not Provide Sufficient Information For Evaluation Will Be Considered Non-responsive. When Submitting This Information, Please Reference The Solicitation Notice Number. the Respondent Must Also Provide Their Unique Entity Id Number From Sam.gov, Organization Name, Address, Point Of Contact, And Size And Type Of Business (e.g., 8(a), Hubzone, Etc., Pursuant To The Applicable Naics Code And Any Other Information That May Be Helpful In Developing Or Finalizing The Acquisition Requirements. one (1) Copy Of The Response Is Required And Must Be In Microsoft Word Or Adobe Pdf Format Using 11-point Or 12-point Font, 8-1/2” X 11” Paper Size, With 1” Top, Bottom, Left And Right Margins, And With Single Or Double Spacing. the Information Submitted Must Be In And Outline Format That Addresses Each Of The Elements Of The Project Requirement And In The Capability Statement /information Sought Paragraphs Stated Herein.  A Cover Page And An Executive Summary May Be Included But Is Not Required. the Response Is Limited To Ten (10) Page Limit.  The 10-page Limit Does Not Include The Cover Page, Executive Summary, Or References, If Requested. the Response Must Include The Respondents’ Technical And Administrative Points Of Contact, Including Names, Titles, Addresses, Telephone And Fax Numbers, And E-mail Addresses. all Responses To This Notice Must Be Submitted Electronically To The Contract Specialist.  facsimile Responses Are Not Accepted. the Response Must Be Submitted To Rashiid Cummins, Contract Specialist At E-mail Address Rashiid.cummins@nih.gov. the Response Must Be Received On Or Before February 20, 2023 At 12:00 Pm, Eastern Time. “disclaimer And Important Notes:  This Notice Does Not Obligate The Government To Award A Contract Or Otherwise Pay For The Information Provided In Response. The Government Reserves The Right To Use Information Provided By Respondents For Any Purpose Deemed Necessary And Legally Appropriate. Any Organization Responding To This Notice Should Ensure That Its Response Is Complete And Sufficiently Detailed To Allow The Government To Determine The Organization’s Qualifications To Perform The Work. respondents Are Advised That The Government Is Under No Obligation To Acknowledge Receipt Of The Information Received Or Provide Feedback To Respondents With Respect To Any Information Submitted. After A Review Of The Responses Received, A Presolicitation Synopsis And Solicitation May Be Published In Federal Business Opportunities. However, Responses To This Notice Will Not Be Considered Adequate Responses To A Solicitation. confidentiality: No Proprietary, Classified, Confidential, Or Sensitive Information Should Be Included In Your Response. The Government Reserves The Right To Use Any Non-proprietary Technical Information In Any Resultant Solicitation(s).”