National Institutes Of Health Tender

This Is A Small Business Sources Sought Notice. This Is Not A Solicitation For Proposals, Proposal Abstracts, Or Quotations. The Purpose Of This Notice Is To Obtain Information Regarding: (1) The Availability And Capability Of Qualified Small Business Sources; (2) Whether They Are Small Businesses; Hubzone Small Businesses; Service-disabled, Veteran-owned Small Businesses; 8(a) Small Businesses; Veteran-owned Small Businesses; Woman-owned Small Businesses; Or Small Disadvantaged Businesses; And (3) Their Size Classification Relative To The North American Industry Classification System (naics) Code For The Proposed Acquisition. Your Responses To The Information Requested Will Assist The Government In Determining The Appropriate Acquisition Method, Including Whether A Set-aside Is Possible. An Organization That Is Not Considered A Small Business Under The Applicable Naics Code Should Not Submit A Response To This Notice. this Notice Is Issued To Help Determine The Availability Of Qualified Companies Technically Capable Of Meeting The Government Requirement And To Determine The Method Of Acquisition.  It Is Not To Be Construed As A Commitment By The Government To Issue A Solicitation Or Ultimately Award A Contract.  Responses Will Not Be Considered As Proposals Or Quotes.  No Award Will Be Made As A Result Of This Notice.  The Government Will Not Be Responsible For Any Costs Incurred By The Respondents To This Notice.  This Notice Is Strictly For Research And Information Purposes Only. background:  To Date, Most Large-scale Genetic Sequencing Efforts For Alzheimer's Disease And Related Dementias Have Been Performed Using Short-read Dna Sequencing. Although These Approaches Can Identify Single Nucleotide Changes And Small Indels, They Are Not Optimized To Identify Large Structural Variations Or Repeat Expansions. Recently Long-read Sequencing Techniques Have Matured And Are Now Ready At Production Level. To Perform The Long-read Sequencing, Dna Needs To Be Isolated And Sheared In Specific Ways To Make Sure The Dna Molecules Are Intact But Also That The Dna Molecules Are All A Similar Length. The Megaruptor 3 Is Designed To Shear Dna Molecules In A Reproduceable Way And Is A Crucial Step Prior To Sequencing. purpose And Objectives: This Acquisition Is Necessary For The Dna Sequencing Techniques For Several Projects Studying Neurodegenerative Disorders. project Requirements: vendor Must Be Able To Provide These Specifications: automated Shearing Independent Of The Source, Concentration, Temperature, Or Salt Content Of A Dna Sample user-friendly Software Allowing For Up To 8 Samples To Be Processed In Parallel Without Additional User Input And Without Cross-contamination software Requires The Operator To Specify Only Three Parameters: The Concentration Of The Sample, The Volume Of Sample, And The Speed Of The Motor That Will Determine The Fragment Sizes high Shearing Efficiency And Highly Reproducible Results For Fragmentation Of Dna In The Range Of 5 Kb- >100 Kb additional Protocols For Low Volumes + High Concentration And Should Be Automatically Adjusted By The Software Depending On The Entered Parameters instrument Should Be Designed To Process Sample Volumes Between 65 Ul And 500 Ul With A Concentration Range Between 0 And 150 Ng/μl quantity: megaruptor 3 (including Main Body + 1 Cassette) Without Syringe And Hydropore   part# B06010003     Qty: 2 anticipated Delivery: 90 Days Aro delivery Location: 9000 Rockville Pike Bldg 10, Rm 8n307 bethesda, Md 20892 capability Statement /information Sought. Respondents Must Provide, As Part Of Their Responses, A Capability Statement Clearly Identifying Their Ability To Provide The Requested Service. the Respondent Must Also Provide Their Duns Number, Organization Name, Address, Point Of Contact, And Size And Type Of Business (e.g., 8(a), Hubzone, Etc., Pursuant To The Applicable Naics Code And Any Other Information That May Be Helpful In Developing Or Finalizing The Acquisition Requirements. one (1) Copy Of The Response Is Required And Must Be In Microsoft Word Or Adobe Pdf Format Using 11-point Or 12-point Font, 8-1/2” X 11” Paper Size, With 1” Top, Bottom, Left And Right Margins, And With Single Or Double Spacing. the Information Submitted Must Be In An Outline Format That Addresses Each Of The Elements Of The Project Requirement And In The Capability Statement /information Sought Paragraphs Stated Herein.  A Cover Page And An Executive Summary May Be Included But Is Not Required. the Response Is Limited To Ten (10) Page Limit.  The 10-page Limit Does Not Include The Cover Page, Executive Summary, Or References, If Requested. the Response Must Include The Respondents’ Technical And Administrative Points Of Contact, Including Names, Titles, Addresses, Telephone And Fax Numbers, And E-mail Addresses. all Responses To This Notice Must Be Submitted Electronically To The Contract Specialist.  Facsimile Responses Are Not Accepted. the Response Must Be Submitted To Rashiid Cummins At E-mail Address Rashiid.cummins@nih.gov. the Response Must Be Received On Or Before July 27th, 2021, 3:00 Pm, Eastern Time. “disclaimer And Important Notes:  This Notice Does Not Obligate The Government To Award A Contract Or Otherwise Pay For The Information Provided In Response. The Government Reserves The Right To Use Information Provided By Respondents For Any Purpose Deemed Necessary And Legally Appropriate. Any Organization Responding To This Notice Should Ensure That Its Response Is Complete And Sufficiently Detailed To Allow The Government To Determine The Organization’s Qualifications To Perform The Work. respondents Are Advised That The Government Is Under No Obligation To Acknowledge Receipt Of The Information Received Or Provide Feedback To Respondents With Respect To Any Information Submitted. After A Review Of The Responses Received, A Presolicitation Synopsis And Solicitation May Be Published In Federal Business Opportunities. However, Responses To This Notice Will Not Be Considered Adequate Responses To A Solicitation. confidentiality: No Proprietary, Classified, Confidential, Or Sensitive Information Should Be Included In Your Response. The Government Reserves The Right To Use Any Non-proprietary Technical Information In Any Resultant Solicitation(s).”