Tender Results of National Institutes Of Health

Notice Of Intent- Rheumatology Professional Services, Sjogren's Syndrome

Sub-visible Particle Characterization Instrument For Ncats

This Is A Small Business Sources Sought Notice. This Is Not A Solicitation For Proposals, Proposal Abstracts, Or Quotations. The Purpose Of This Notice Is To Obtain Information Regarding: (1) The Availability And Capability Of Qualified Small Business Sources; (2) Whether They Are Small Businesses; Hubzone Small Businesses; Service-disabled, Veteran-owned Small Businesses; 8(a) Small Businesses; Veteran-owned Small Businesses; Woman-owned Small Businesses; Or Small Disadvantaged Businesses; And (3) Their Size Classification Relative To The North American Industry Classification System (naics) Code For The Proposed Acquisition. Your Responses To The Information Requested Will Assist The Government In Determining The Appropriate Acquisition Method, Including Whether A Set-aside Is Possible. An Organization That Is Not Considered A Small Business Under The Applicable Naics Code Should Not Submit A Response To This Notice. this Notice Is Issued To Help Determine The Availability Of Qualified Companies Technically Capable Of Meeting The Government Requirement And To Determine The Method Of Acquisition.  It Is Not To Be Construed As A Commitment By The Government To Issue A Solicitation Or Ultimately Award A Contract.  Responses Will Not Be Considered As Proposals Or Quotes.  No Award Will Be Made As A Result Of This Notice.  The Government Will Not Be Responsible For Any Costs Incurred By The Respondents To This Notice.  This Notice Is Strictly For Research And Information Purposes Only. background:  The National Institute On Aging, Laboratory Of Neurogenetics Works To Understand The Pathological Basis Of Neurodegenerative Diseases Mainly Alzheimer’s Disease. The Purpose Of This Acquisition Is To Provide A Dna Analyzer For Analysis Of Dna Changes Associated With Alzheimer’s Disease And Other Neurodegenerative Disease Disorders. A Dna Analyzer Is A Powerful, Standard Genetic Analysis Device That Provides Microsatellite-based Fragment Analysis, De Novo Sequencing, Resequencing, And Single-nucleotide Polymorphism (snp) Genotyping Analysis. purpose And Objectives: This Acquisition Is Necessary For Dna Sequencing And Analysis Of Dna Samples To Support The Research Of Novel Amino Acid Mutation Discoveries In The Scope Of Alzheimer’s Disease Research Within The Laboratory Of Neurogenetics. salient Characteristics: instrument Shall Be Designed To Allow The Use Of Both 48 Or 96 Capillary Arrays In Either Of Two Lengths, 36-cm And 50-cm, Without The Need For Any Hardware Modifications. the Instrument Capillary Array Shall Be Constructed Using Internally Uncoated Capillaries And Warranted For 300 Sample Runs. the Instrument Shall Be Able To Process Successive Runs Without Requiring A Capillary Array Washing Or Conditioning Step. the Instrument Shall Be Able To Process 768- 6912 Sequencing Analysis Samples In 24 Hours. the Instrument Shall Be Able To Process At Least 3,000 Fragment Analysis Samples In 24 Hours. the Instrument Shall Be Capable Of Housing 16 Sample Plates, Either 96-well, 384-well Or A Combination Of, Simultaneously. the Instrument Shall Be Designed To Allow Users To Add Or Remove Sample Plates From The Instrument Without Interrupting The Run Progress. the Instrument Shall Be Able To Detect And Analyze Six Fluorescent Dyes Simultaneously. the Instrument Shall Be Designed To Allow Semi-automated On-board Cleaning Of The Automated Separation Matrix (polymer) Capillary Filling Mechanism Without The Need To Remove Or Disassemble Any Capillary Filling Mechanism Components Other Than To Flush The Water Fill Trap Monthly. the Instrument Shall Have An Internal Barcode Reader That Scans And Recognizes The Following Types Of Barcodes On Sample Plates: Code 128, Code 39, Code 93, Logmars, And Ean-8. the Instrument Shall Be Designed To Provide An Onboard Piercing Mechanism (enclosed Inside The System) For Piercing Of Sealing Film Covering The Sample Plates. the Instrument Shall Be Designed To Provide A Thermally Stable Detection Region Of The Capillary Array. the Instrument Shall Employ A Fixed Single Solid-state Laser Which Operates In Single Longitudinal Mode And Illuminates All Capillaries In The Array Simultaneously. The Instrument’s Solid-state Laser Shall Have A 10,000-hour Warranty Life Span. quantity: 3730xl-48/96 Gen Alyzr                                          Sku# A41046            Qty: 1 software Bundle*                                                          Sku# 4443764          Qty: 1 3730 Bdt V3.1 Seq/frag Install Kit                    Sku# 4337193          Qty: 1 96well Septa Plate Kit 3730 Each                     sku# 4336131          Qty: 1 3730xl 96x36cm Cap Array Instl Kit                  Sku# 4339251          Qty: 1 hi-di Formamide Bottle 25 Ml                             sku# 4311320          Qty: 1 3730 Buffer(10x) W/edta 500ml Each                 sku# 4335613          Qty: 1 pop7-3730/3730xl Dna Analyzers Sin                 sku# 4363929          Qty: 1 sw, Genemapper V6b 5 Client Lic Combo Kit Sku# A45741            qty: 1 *a Software Bundle Consisting Of Windows 10 And Windows 7 Compatible Versions Of All Ce Secondary Analysis Software (sequencing Analysis Software 7, Seqscape 4, Variant Reporter 3, Genemapper 6) anticipated Delivery: 6 Months After Receipt Of Order capability Statement /information Sought. Respondents Must Provide, As Part Of Their Responses, A Capability Statement Clearly Identifying Their Ability To Provide The Requested Service. the Respondent Must Also Provide Their Duns Number, Organization Name, Address, Point Of Contact, And Size And Type Of Business (e.g., 8(a), Hubzone, Etc., Pursuant To The Applicable Naics Code And Any Other Information That May Be Helpful In Developing Or Finalizing The Acquisition Requirements. one (1) Copy Of The Response Is Required And Must Be In Microsoft Word Or Adobe Pdf Format Using 11-point Or 12-point Font, 8-1/2” X 11” Paper Size, With 1” Top, Bottom, Left And Right Margins, And With Single Or Double Spacing. the Information Submitted Must Be In An Outline Format That Addresses Each Of The Elements Of The Project Requirement And In The Capability Statement /information Sought Paragraphs Stated Herein.  A Cover Page And An Executive Summary May Be Included But Is Not Required. the Response Is Limited To Ten (10) Page Limit.  The 10-page Limit Does Not Include The Cover Page, Executive Summary, Or References, If Requested. the Response Must Include The Respondents’ Technical And Administrative Points Of Contact, Including Names, Titles, Addresses, Telephone And Fax Numbers, And E-mail Addresses. all Responses To This Notice Must Be Submitted Electronically To The Contract Specialist.  Facsimile Responses Are Not Accepted. the Response Must Be Submitted To Rashiid Cummins At E-mail Address Rashiid.cummins@nih.gov. the Response Must Be Received On Or Before June 11th, 2021, 3:00 Pm, Eastern Time. “disclaimer And Important Notes:  This Notice Does Not Obligate The Government To Award A Contract Or Otherwise Pay For The Information Provided In Response. The Government Reserves The Right To Use Information Provided By Respondents For Any Purpose Deemed Necessary And Legally Appropriate. Any Organization Responding To This Notice Should Ensure That Its Response Is Complete And Sufficiently Detailed To Allow The Government To Determine The Organization’s Qualifications To Perform The Work. respondents Are Advised That The Government Is Under No Obligation To Acknowledge Receipt Of The Information Received Or Provide Feedback To Respondents With Respect To Any Information Submitted. After A Review Of The Responses Received, A Presolicitation Synopsis And Solicitation May Be Published In Federal Business Opportunities. However, Responses To This Notice Will Not Be Considered Adequate Responses To A Solicitation. confidentiality: No Proprietary, Classified, Confidential, Or Sensitive Information Should Be Included In Your Response. The Government Reserves The Right To Use Any Non-proprietary Technical Information In Any Resultant Solicitation(s).”

Noi Uct50 Scanner Maintaince Services

Comprehensive And Rapid Response To Niaid Research Programs

Sources Sought: Nuclear Magnetic Resonance Spectrometer

Sources Sought: Linux Workstation

To Procure An Upgrade Of Abi 3730 Genetic Analyzer

This Is A Small Business Sources Sought Notice. This Is Not A Solicitation For Proposals, Proposal Abstracts, Or Quotations. The Purpose Of This Notice Is To Obtain Information Regarding: (1) The Availability And Capability Of Qualified Small Business Sources; (2) Whether They Are Small Businesses; Hubzone Small Businesses; Service-disabled, Veteran-owned Small Businesses; 8(a) Small Businesses; Veteran-owned Small Businesses; Woman-owned Small Businesses; Or Small Disadvantaged Businesses; And (3) Their Size Classification Relative To The North American Industry Classification System (naics) Code For The Proposed Acquisition. Your Responses To The Information Requested Will Assist The Government In Determining The Appropriate Acquisition Method, Including Whether A Set-aside Is Possible. An Organization That Is Not Considered A Small Business Under The Applicable Naics Code Should Not Submit A Response To This Notice. this Notice Is Issued To Help Determine The Availability Of Qualified Companies Technically Capable Of Meeting The Government Requirement And To Determine The Method Of Acquisition.  It Is Not To Be Construed As A Commitment By The Government To Issue A Solicitation Or Ultimately Award A Contract.  Responses Will Not Be Considered As Proposals Or Quotes.  No Award Will Be Made As A Result Of This Notice.  The Government Will Not Be Responsible For Any Costs Incurred By The Respondents To This Notice.  This Notice Is Strictly For Research And Information Purposes Only. background:  To Date, Most Large-scale Genetic Sequencing Efforts For Alzheimer's Disease And Related Dementias Have Been Performed Using Short-read Dna Sequencing. Although These Approaches Can Identify Single Nucleotide Changes And Small Indels, They Are Not Optimized To Identify Large Structural Variations Or Repeat Expansions. Recently Long-read Sequencing Techniques Have Matured And Are Now Ready At Production Level. To Perform The Long-read Sequencing, Dna Needs To Be Isolated And Sheared In Specific Ways To Make Sure The Dna Molecules Are Intact But Also That The Dna Molecules Are All A Similar Length. The Megaruptor 3 Is Designed To Shear Dna Molecules In A Reproduceable Way And Is A Crucial Step Prior To Sequencing. purpose And Objectives: This Acquisition Is Necessary For The Dna Sequencing Techniques For Several Projects Studying Neurodegenerative Disorders. project Requirements: vendor Must Be Able To Provide These Specifications: automated Shearing Independent Of The Source, Concentration, Temperature, Or Salt Content Of A Dna Sample user-friendly Software Allowing For Up To 8 Samples To Be Processed In Parallel Without Additional User Input And Without Cross-contamination software Requires The Operator To Specify Only Three Parameters: The Concentration Of The Sample, The Volume Of Sample, And The Speed Of The Motor That Will Determine The Fragment Sizes high Shearing Efficiency And Highly Reproducible Results For Fragmentation Of Dna In The Range Of 5 Kb- >100 Kb additional Protocols For Low Volumes + High Concentration And Should Be Automatically Adjusted By The Software Depending On The Entered Parameters instrument Should Be Designed To Process Sample Volumes Between 65 Ul And 500 Ul With A Concentration Range Between 0 And 150 Ng/μl quantity: megaruptor 3 (including Main Body + 1 Cassette) Without Syringe And Hydropore   part# B06010003     Qty: 2 anticipated Delivery: 90 Days Aro delivery Location: 9000 Rockville Pike Bldg 10, Rm 8n307 bethesda, Md 20892 capability Statement /information Sought. Respondents Must Provide, As Part Of Their Responses, A Capability Statement Clearly Identifying Their Ability To Provide The Requested Service. the Respondent Must Also Provide Their Duns Number, Organization Name, Address, Point Of Contact, And Size And Type Of Business (e.g., 8(a), Hubzone, Etc., Pursuant To The Applicable Naics Code And Any Other Information That May Be Helpful In Developing Or Finalizing The Acquisition Requirements. one (1) Copy Of The Response Is Required And Must Be In Microsoft Word Or Adobe Pdf Format Using 11-point Or 12-point Font, 8-1/2” X 11” Paper Size, With 1” Top, Bottom, Left And Right Margins, And With Single Or Double Spacing. the Information Submitted Must Be In An Outline Format That Addresses Each Of The Elements Of The Project Requirement And In The Capability Statement /information Sought Paragraphs Stated Herein.  A Cover Page And An Executive Summary May Be Included But Is Not Required. the Response Is Limited To Ten (10) Page Limit.  The 10-page Limit Does Not Include The Cover Page, Executive Summary, Or References, If Requested. the Response Must Include The Respondents’ Technical And Administrative Points Of Contact, Including Names, Titles, Addresses, Telephone And Fax Numbers, And E-mail Addresses. all Responses To This Notice Must Be Submitted Electronically To The Contract Specialist.  Facsimile Responses Are Not Accepted. the Response Must Be Submitted To Rashiid Cummins At E-mail Address Rashiid.cummins@nih.gov. the Response Must Be Received On Or Before July 27th, 2021, 3:00 Pm, Eastern Time. “disclaimer And Important Notes:  This Notice Does Not Obligate The Government To Award A Contract Or Otherwise Pay For The Information Provided In Response. The Government Reserves The Right To Use Information Provided By Respondents For Any Purpose Deemed Necessary And Legally Appropriate. Any Organization Responding To This Notice Should Ensure That Its Response Is Complete And Sufficiently Detailed To Allow The Government To Determine The Organization’s Qualifications To Perform The Work. respondents Are Advised That The Government Is Under No Obligation To Acknowledge Receipt Of The Information Received Or Provide Feedback To Respondents With Respect To Any Information Submitted. After A Review Of The Responses Received, A Presolicitation Synopsis And Solicitation May Be Published In Federal Business Opportunities. However, Responses To This Notice Will Not Be Considered Adequate Responses To A Solicitation. confidentiality: No Proprietary, Classified, Confidential, Or Sensitive Information Should Be Included In Your Response. The Government Reserves The Right To Use Any Non-proprietary Technical Information In Any Resultant Solicitation(s).”

Ipa Analysis Match Explorer Cl