Data Center Tenders

Details: Description 1 Lot Supply And Delivery Of Various Ict Equipment The Inclusion Are As Follows: 1) 5 Units Heavy-duty Printers • Printer Type: Laser • Printer Output: Colored • Print Speed: Color And Black - Capable For 30 Pages Per Minute (ppm) • Print Resolution: Up To 2400 X 600 Dpi • Paper Size: A4 / Legal • Printing Setting: Automatic 2-sided Printing • Interface: - With Usb (hi-speed Usb 2.0) - Network Based (10/100/1000 Based) - Wireless Lan: Ieee 802.11b/g/n With Wifi Direct • Network: 2 X 10 Gbe Network Interfaces, 1 X 1 Gbe Management Interface • Ink Yield: Standard (approx. 3,000 Pages For Black, Approx. 1,800 Pages For Color) • Lead Time For Ink Delivery: Within 30 Calendar Days From Receipt Of Purchase Order • With Additional 1 Set Of Black And Colored Printing Toners (original / Genuine) • Note: Supplier Must Provide Toner Price • With Complete Accessories And Peripherals • Warranty: At Least 1 Year Of Warranty With Active Authorized Service Center Within The Locality • Warranty Period: 3 Years On Service Maintenance 2) 6 Units Heavy-duty Laptops • Processor: At Least Clock Speed Of At Least 2.5 Ghz, Quad-core • Graphics: With Dedicated Graphics Card • Ram: At Least 8gb • Storage: - 1 512 Ssd For Operating System And Applications - 1 Tb Hdd For Data Storage • Display: At Least 15.6" Fhd Display, With Anti-glare And Led Backlighting • Resolution: Hd, At Least 1920 By 1080 Pixels, With Aspect Ratio Of 16:9 • Os: With Licensed Os, Ability To Run Applications Developed For 32-bit And 64-bit Architecture And Support Common Productivity Tools With Graphical User Interface • Features: With 2 Usb 2.0 And 1 Usb 3.0, 1 Hdmi Port, 1 Rj-45 Ethernet Port, With Wifi And Bluetooth Technology, With Built-in Microphone, Speakers And Camera, Backlit Keyboard And Numeric Keypad, And Fingerprint Reader • Battery-run Time: At Least 6 Hours Battery Life • With Complete Accessories And Peripherals • Inclusive Of Proprietary Licensed Document Processing Software • Inclusive Of Laptop Bag • Warranty: At Least 1 Year Of Warranty With Active Authorized Service Center Within The Locality 3) 2 Units Heavy-duty All-in-one Pc • Processor: At Least 2.1 Ghz Base Clock, Up To 3.7 Ghz Max Boost Clock, 4 Mb L3 Cache, 4 Cores • Ram: At Least 16 Gb Ddr4-2400 Sdram • Storage: - At Least 512 Gb Ssd For Operating System And Applications - At Least 1 Tb Hdd For Data Storage • Display: At Least 27" Fhd Display, With Anti-glare, Ips And Led Backlighting • Graphics: With Dedicated Graphics Card • Os: With Licensed Os For Data Center Operations Ability To Run Applications Developed For 32-bit And 64-bit Architecture And Support Common Productivity Tools With Graphical User Interface • Features: With 3-in-1 Memory Card Reader, 2 Usb 2.0, 1 Usb 3.0, 1 Hdmi Port, 1 Rj-45 Ethernet Port, With Wifi And Bluetooth Technology, With Built-in Microphone, Speakers And Camera • Power: At Least 650 W Psu Or Equivalent To Standards • Network Interface: Integrated 10/100/1000 Gigabit Ethernet Lan • With Complete Accessories And Peripherals • Inclusive Of Proprietary Licensed Document Processing Software • Warranty: At Least 1 Year Of Warranty 4) 5 Units Network Switch • Type: Layer 3 Manageable • Ports: 48 Ports Giga-bit Ports • Routing Capability: Supports Layer 3 Static Routing • Poe: Supports Power-over-ethernet (poe) Enabled • Vlan: Supports Vlan Configuration And Management For Network Segmentation • Management Interface: With Friendly Graphical User Interface Web Management • Terminal: Capable For Terminal Remote Access Management / Cli • Operating Temperature: Suitable For Usual Standards For Server Room/office Environments • Uplink Ports: Supports 10/100/1000 Gbps Uplink Speed / Ports • Features: Rack-mounted With Screws, Bolts, And Nuts, With Usb Port • With Complete Accessories And Peripherals (inclusive Of Serial / Com Port) • Warranty: At Least 1 Year Of Warranty 5) 1 Unit Server (heavy-duty) • Processor: At Least V4 Processors, 2 Ghz, 14 Cores, 28 Threads • Ram: 32 Gb Ddr4 Ram, 2400 Mhz, Ecc, Registered • Storage: - 2 X 2 Tb Ssd (sata Iii, 6 Gb/s, 2.5"") For Operating System And Applications; - 2 X 2 Tb Hdd (sata Iii, 6 Gb/s, 3.5"") For Data Storage, Configured In Raid 10 • Power Supply: 2 X 750 W, With Redundant Power Supply/dual Power Supply • Raid: Hardware Raid Controller, Raid 10 Configuration • Network: 2 X 10 Gbe Network Interfaces, 1 X 1 Gbe Management Interface • Operating System: With Licensed Os For Server, Ability To Manage, Host And Run Applications Developed For 64-bit Architecture And Support Advanced Server Management Policies Productivity Tools With Graphical User Interface • Features: Pre-installed/configured, Rack-mounted With Screws, Bolts And Nuts, With Licensed Active Directory Service / Group Management And Remote Management Service (built-in), With Ups (at Least 2kva Ups), With 1 Usb 3.0 And 2 Usb 2.0, And Capable For At Least 2 Virtual Machine Configurations • With Complete Accessories And Peripherals • Warranty: At Least 2 Years Of Warranty • Note: Ensure Compatibility With Neda Co And Neda Xi Existing Information Systems • Ups Battery Time: At Least 2 Hours Standby Operating Time

Details: The U.s. Department Of Transportation, John A. Volpe National Transportation Systems Center (volpe Center) Cambridge, Ma, Is Supporting The Federal Aviation Administration (faa), In Its Aircraft-specific Air Quality Model Development And Airport Air Quality Assessment Effort, Including Project Resource Management And Data Processing. The Volpe Center Seeks The Support Of The Contractor With Sole Access To Lasat For Airport (lasport) Modeling Platform, To Perform Modeled Air Quality Assessment For Lax, One Us Airport. Therefore, The Government Intends To Award A Purchase Order On A Sole Source Basis To Janicke Consulting. The Period Of Performance Will Be From Date Of Award Through 09/30/2024. The Anticipated Award Date Is On Or About 01/08/2024. The Naics Code For This Procurement Is 541620; The Small Business Size Standard Is $19.0m.

Details: Description Specification Supply Of Rack Mounted Server To Be Used For Iskolar And Other Is Project Project/purpose: For Hosting Of Iskolar And Other Information Systems Processor Intel(r) Xeon(r) Gold 6244 Cpu @ 3.60ghz Number Of Core Processors 16 Ram 320gb Storage Nvme Ssd At 6tb Power Supplies Hot Plug Power Supplies With Full Redundancy Option Up To 8 Hot Plugs Fans With Full Redundancy Dimension Form Factor: Rack 1u Security Tpm 1.2/2.0, Tcm 2.0 Optional Cryptographically Signed Firmware Secure Boot I/o & Ports Network Options: 2 X 10gbe + 2 X 1gbe Front Ports (minimum): 2 X Usb 3.0 1 X Video Operating System Ubuntu Server Other Inclusions With Dvd-rom, Dvd-rw With Raid Support With Embedded Management Supply And Installation Monitor Mouse Keyboard Warranty 5-year Software And Manufacturer’s Warranty *equivalent Is Defined As A Model From Another Manufacturer That Is Within 5% Of Benchmark Scores As Determined By The Benchmark Tool Chosen By The Ims Terms Of Reference Background Of The Item Being Procured General Overview Of The Procurement Project The Information Management Service (ims) Of The University Of The Philippines Manila (upm) Is Acquiring High Performance Rack Mounted Servers To Meet The Universities Growing Computing Needs And Support New Critical Applications Such As Iskolar And Other New Information Systems Developed By The Ims Team Brief Description Of The Item Being Procured The Item Being Procured Is Based On The Intended User And Its Needs. The New Rack Mounted Servers Should Be High-performance, Scalable, Reliable And Secure To Meet The Universities. The Goal Is To Support The Production Of The New Information Systems While Improving Our Digital Infrastructure. Abc Of The Project And Fund Source The Abc Of The Project Is Six Million Pesos (php6,000,000.00) The Fund Source Is The Up-manila Funds Detailed Financial Breakdown Item Qty Unit Cost Total Price Rack Mounted Servers 2 Un Php 3,000,000.00 Php 6,000,000.00 Total Php 6,000,000.00 Mode Of Procurement The Mode Of Procurement Will Be Competitive Bidding Procurement, In Accordance With The Provisions Of The Government Procurement Reform Act (ra 9184). Nature Of Procurement Goods And Services, Including Hardware, Software, And Training Modules. Scope Of Work The Selected Vendor Shall Be Responsible For The Supply And Installation Of 2 Units Of Rack Mounter Servers. The Vendor Shall Provide The Following Documents With The Delivery: User Manuals For Each Unit. Warranty Certificates Installation Guide The Selected Vendor Should Provide Rack Mounted Servers That Meet Or Exceed The Minimum Technical Requirements. (all Specifications And Details Are Attached Together With This Document) Warranty And Support The Vendor Must Provide A Minimum Of A 5 Years Of Warranty For The 2 Rack Mounted Servers. Warranty Includes Parts, Labor, And On-site Support For Any Technical Issues Or Failures The Supplier Must Provide After-sales Technical Support The Vendor Must Endure The Availability Of Replacement Parts During The Warranty Period Deployment The Rack Mounted Server Should Be Deployed And Installed In The Ims Data Center. Terms And Conditions Indicate Brand, Model, And Country Of Origin. Notarized Certificate That The Product Is Brand New, Not Reconditioned/refurbished Including Parts And Accessories. Delivery And Installation Should Be Done Within 30 Calendar Days Commencing On The Date Of Receipt Of Purchase Order And Notice To Proceed. Notification By Email And Acknowledged By The Supplier Constitutes The Date Of Acceptance The Equipment Must Be Delivered Ready To Use. Cables, Connectors, Adapters, And Accessories Even Not Specified But Are Essential For The Unit To Function Must Be Provided Free By The Winning Bidder. Certification From At Least Three (3) Government And /or Private Agencies Within Metro Manila Or The Philippines That They Have Been Supplied With The Same Brand Being Offered. Undertaking To Provide Product Orientation And Operations Training For End-user And Troubleshooting Training For Technicians/research Staff. Warranty Should Be At Least 5 Years For Service And 5 Years For Parts For The 2 Rack Mounted Servers Warranty Period Shall Commence From The Date Of Acceptance By The End-user, Testing And Commissioning. Provide Regular Quarterly Preventive Maintenance And Calibration During The Warranty Period. A Notarized Certification From The Manufacturer That The Contractor Is An Authorized Distributor Of The Equipment. Notarized Certification From The Manufacturer And Local Distributor That In The Event Of A Change Of Local Distributor, Preventive Maintenance, Warranty, And Services Agreed Here Upon Will Be Honored By The Principal Manufacturer. Notarized Certification That The Local Distributor And The Manufacturer Have Been In Business Relationship Of Providing That Said Equipment For At Least Five (5) Years. Notarized Certification Accompanied With Proof That The Contractor Is In The Business Of Supplying The Unit/item For The Last Five (5) Years. Guarantee Letter Or Certificate From The Manufacturer And Local Distributor To Ensure The Availability Of Parts, Supplies And Accessories And Will Not Be Discontinued For The Next Five (5) Years. Provide Separate Quotations For Maintenance, Repair, And Replacement Of Parts After Warranty Period. Provide Operator’s & Service Manual (in English Language) Upon Delivery. The Bidder Must Submit Certification That They Have A Capability For Corrective And Preventive Maintenance Of The Unit Or Have A Service Center Within Metro Manila Must Guarantee That The Diagnostic Technician Will Be Able To Assess The Unit Within 24 Hours Of Notification (if Applicable). Automatic Provision Of A Functioning Service Unit (same Model Or Higher) In Case Repair Of More Than 3 Days/pull Out Of The Purchased Unit During The Warranty Period. The Winning Bidder Will Be Responsible For All Fees For Performance Testing, Delivery, Installation And Commissioning The Unit (if Applicable). Specific Place Of Delivery: 2nd Flr. Ims Office Information Technology Center (itc), Joaquin Gonzalez Compound, Up Manila, Padre Faura St., Ermita, Manila. Metro Manila~manila - Ermita - Barangay 669. In Case Of Large Equipment, The End-user Should Issue A Certification, Noted By The Dean/director, That The Identified Space Is Available, Terms Of Payment: Payment Must Only Be Made After The Appropriate Inspection And Acceptance Procedures, As Mandated By Existing Government Rules And Regulations, Have Been Complied With By The Procuring Entity. Testing And Acceptance The Vendor Must Ensure That All Rack Mounted Servers Are Fully Functional And Ready For Use Upon Delivery. Inspection By The Ims And Spmo To Verify The Functionality, Compliance With Specifications, Quantity And Overall Quality Of The Rack Mounted Servers Rack Mounted Servers Will Be Considered Accepted Upon Successful Completion Of Testing And Verification The Vendor Must Comply With The Indicated Specifications And Scope Of Work Written In This Document Other Requirements Vendor Must Meet The Following Eligibility Criteria And Have Proven Experience In Supply And Installation Of Rack Mounted Servers Eligibility Requirements: Valid Mayor's Permit Valid Philgeps Registration Income/business Tax Return Omnibus Sworn Statement

Purchaser Name: Data Center of the National Financial Administration of the NRW | To the tender 'delivery of postal code data'

Details: The Work For This Project Includes, But Is Not Limited To, The Construction Of A Multi-story Communications Center Facility To Support Naval Computer And Telecommunications Station Guam Operations. Special Features Include Sensitive Compartmented Information Facility Construction Work In Accordance With Icd/ics 705 And Demolition And Incidental Related Work. Secure Facility Construction Shall Be Performed By U.s. Companies Using U.s. Citizens. the Work Will Also Include Three (3) Pre-priced Options For The Construction Of Two (2) Single-story Warehouse Facilities, And Osp Fiber Line Sonet Ring. In Accordance With Far 52.217-7 Option For Increased Quantity – Separately Priced Line Item, The Government May Exercise The Options By Written Notice To The Contractor Within 365 Days Of Contract Award. the Magnitude Of This Project Is Estimated Between $250,000,000 And $500,000,000. The North American Industry Classification System (naics) Code Is 236220 And Average Annual Receipts Of $45 Million Over The Past Three Years. The Contract Completion Period Is Anticipated To Be 1,255 Calendar Days. a Sources Sought Notice (n62742sscomms) For This Procurement Was Posted On 22 August 2023 On The System For Award Management (sam) Website Https://www.sam.gov/, And A Market Survey Was Conducted That Included An Assessment Of Relevant Qualifications And Capabilities Of Potentially Qualified Firms. As A Result Of The Market Research Analysis, A Determination Was Made To Solicit This Procurement On An Unrestricted Basis Inviting Full And Open Competition. this Solicitation Will Utilize The Tradeoff Source Selection Process. All Technical Factors, When Combined, Are Considered Of Equal Importance To Past Performance. The Factors Are: Factor 1 – Experience, Factor 2 – Safety, Factor 3 – Small Business Utilization And Participation, Factor 4 – Past Performance, And Price. Contract Award Will Be Made To The Offeror Proposing The Best Value To The Government From A Non-price And Price Standpoint. Furthermore, A Relevant Construction Project Is Defined As A Construction Project That Includes At Least One Of The Following Individual Features: (1) Precision Cooling System. New Construction Of A Chiller Type Technology Cooling System Engineered Specifically For Data Center/electronic/it Networking Environments. Projects Submitted Which Reference Comfort Cooling Systems Which Are Engineered Primarily For The Intermittent Use Required To Maintain A Comfortable Environment For People In Facilities Will Not Be Considered. Projects Submitted To Demonstrate Precision Cooling System Will Only Be Considered If The Work Was Performed By The Specific Entity Proposed For The Precision Cooling System Under The Resultant Contract, As Identified In Block 1 Of Attachment A. (2) Uninterruptable Power Supply System. New Construction Of An Uninterruptible Power Supply (ups) System That Is 225 Kva Size Or More. Projects Submitted To Demonstrate Ups System Experience Will Only Be Considered If The Work Was Performed By The Specific Entity Proposed For The Ups System, As Identified In Block 1 Of Attachment A. (3) Clean Agent Fire Suppression System. New Construction Or Replacement Of A Clean Agent Fire Extinguishing System And Releasing System, Including All Mechanical, Controls And Electrical Components Necessary For A Complete And Operating Clean Agent Fire Suppression System. Projects Submitted To Demonstrate Clean Agent Fire Suppression System Experience Will Only Be Considered If The Work Was Performed By The Specific Entity Proposed For The Clean Agent Fire Suppression System, As Identified In Block 1 Of Attachment A. see Request For Proposal (rfp) Document 00 21 16. the Rfp, Including The Specifications And Drawings, Can Be Accessed By Approved Individuals Via The Sam Website At Https://sam.gov/. Approved Individuals Must Register At The Sam Website To Obtain Access To The Rfp. Registration Instructions Can Be Found On The Sam Website. Once Registered In Sam, Approved Individuals Must Request Explicit Access To View The Documents. An Email Will Be Forwarded Once The Contracting Office Has Approved Or Declined The Request. Approved Individuals May View And/or Download The Rfp Documents. Amendments Will Also Be Posted At Https://sam.gov/. It Is Highly Recommended That Firms Register On The Sam Website As This Will Be The Only Plan Holder’s List Available. It Is The Offeror’s Responsibility To Check The Sam Website Periodically For Any Amendments To The Solicitation. offerors Are Required To Be Registered In The Sam Database At Https://www.sam.gov At The Time Of Proposal Submission. see Document 00 21 16 For Pre-proposal Site Visit Information. This Site Visit Is To Provide Offerors With An Opportunity To Familiarize Themselves With The Jobsite And Conditions To Be Encountered And Is Not For The Purpose Of Answering Questions. Forms Submission To Ms. Merbby Corpuz At Merbbyjoyce.n.corpuz.civ@us.navy.mil On Or Before 31 October 2024, 2:00 P.m., Hawaii Standard Time (hst). (1) Current Dbids. If An Interested Attendee Has Current Dbids Credentials For The Specific Base Where The Project Is Located, Submit The Following: company Letter Template: One Letter Required Per Company. List Attendees In Alphabetical Order (by Last Name). Must Be Signed By A Person Authorized To Provide The Certification Required. request For Camera Pass Form: Applicable Only For Those With Dbids Credentials Who Will Be Taking Photos. One Letter Required Per Company. Dbids Number Is Required On The Form. Once Properly Submitted To The Poc In Subparagraph (c) Above And Once Approved, You Will Receive A Routing Number From The Poc. An Appointment With The Naval Base Guam (nbg) Visitor’s Control Center (vcc) Is Required To Complete The Processing Of Your Camera Pass. (2) Current Dbids Not For The Specific Base Where The Project Is Located. Submit The Following: company Letterhead Template: One Letter Required Per Company. List Attendees In Alphabetical Order (by Last Name). Must Be Signed By A Person Authorized To Provide The Certification Required. dbids Base Access Request Form: Each Attendee Please Read, Complete, And Sign/date. Typewritten Is Preferred. Any Handwritten Forms Must Be Legible. email The Vcc At M-gu-nbg-n3at-vcc@fe.navy.mil To Have Their Dbids Programmed With The Specific Base Where The Project Is Located. Prior To Emailing The Vcc, Please Submit The Company Letter And The Dbids Base Access Request Form To The Poc In Subparagraph (c) Above For Approval. Once Approved, The Documents Will Be Sent Back To You For Submission To The Ngb Vcc Along With The Request To Have The Dbids Cards Programmed With The Specific Base Where The Project Is Located. request For Camera Pass Form: Applicable Only For Those With Dbids Credentials Who Will Be Taking Photos. One Letter Required Per Company. Dbids Number Is Required On The Form. Once Properly Submitted To The Poc In Subparagraph (c) Above And Once Approved, You Will Receive A Routing Number From The Poc. An Appointment With The Naval Base Guam (nbg) Visitor’s Control Center (vcc) Is Required To Complete The Processing Of Your Camera Pass. (2) No Dbids Credentials. Submit The Following: company Letterhead Template: One Letter Required Per Company. List Attendees In Alphabetical Order (by Last Name). Must Be Signed By A Person Authorized To Provide The Certification Required. secnav 5512/1 Form: Each Attendee Shall Read, Complete, And Sign/date Form. Typewritten Is Preferred. Any Handwritten Forms Must Be Legible. Do Not Submit The Secnav 5512/1 Form To The Government. The Contractor Is Responsible For Either Hand-carrying Or Emailing This Document To The Ngb Vcc Along With Any Other Pertinent Document Listed In This Subparagraph. dbids Base Access Request Form: Each Attendee Please Read, Complete, And Sign/date. Typewritten Is Preferred. Any Handwritten Forms Must Be Legible. naval Base Guam Foreign National Base Access Request Form (applicable To Foreign Nationals Only). Each Attendee Please Read And Complete. fn Biometric Data Form (applicable To Foreign Nationals Only): Each Attendee Please Read And Complete. request For Camera Pass Form: Applicable Only For Those With Dbids Credentials Who Will Be Taking Photos. One Letter Required Per Company. Once You Have A Routing Number From The Vcc For Your Dbids Application, Insert That Number On The Form. Once Properly Submitted To The Poc In Subparagraph (c) Above And Once Approved, You Will Receive A Routing Number From The Poc. An Appointment With The Naval Base Guam (nbg) Visitor’s Control Center (vcc) Is Required To Complete The Processing Of Your Camera Pass.

Purchaser Name: Awarding Office For The Municipal Data Center In The Lower Rhine Region | To the call for proposals 'suse Renewal 2024'

Details: Description October31,2024 Requestforquotation No.:2024-cims(018)-npsvp-0053 Procurementofexistingsslcertificates (negotiatedprocurement–smallvalueprocurement) Sir/madam: Thecreditinformationcorporationthroughcreditinformationmanagementservices Invitesyouto Submityourquotation/offerfortheitem/sdescribedbelowusingthe Price Proposal Form (see Annex "a") Subject To The Terms And Conditions Stated In The Rfq And Terms Of Reference (see Annex “b”). Qty Uom Particulars Unitcost (in Php) Approved Budgetforthe Contract(abc In Php) 1.certificatesforone(1)year Organizationvalidationwildcard Ssl Commonname: *.creditinfo.gov.ph *.creditinfo.com.ph *.creditinfodev.com.ph 2.certificatesforone(1)year 1 Lot Extendedvalidationssl 316,700.00 316,700.00 -a2a-test.creditinfo.com.ph -a2a.creditinfo.com.ph -online.creditinfo.com.ph -wftp.creditinfo.com.ph -ftp-test.creditinfo.com.ph -ftp.creditinfo.com.ph -online-test.creditinfo.com.ph -sftp.creditinfo.com.ph Contractduration:one(1)year Delivery Site: 6f,exchangecornerbldg.,107varufinost.cor.estebanst., Legaspi Village, Makati City Submit Your Proposal, Together With The Following Documents, Duly Signed By You Or Your Duly Authorized Representative, Not Later Than November 7, 2024, 5:00 P.m. Philgepscertificate/number; Mayor’s/businesspermitforthecurrentyear; Notarizedomnibusswornstatement(annexc);and For Authorized Representatives: Spa (sole Proprietorship/partnership), Secretary’s Certificate Or Board Resolution (corporation). Note: Philgeps Platinum Registration Certificate May Be Submitted In Lieu Of Philgeps Number,andmayor’s/businesspermitforthecurrentyear Onlyone(1)setofdocumentscertifiedtobetruecopiesoftheoriginalshallberequired. Proposals And Other Documents Required Shall Be Sent Electronically To Procurementunit@creditinfo.gov.ph.electronically Submitted Proposals And Documents Must Be Submitted On Or Before The Deadline Of Submission As Stated In This Rfq. Upon Determination Of Your Technical, Legal And Financial Eligibility, The Administration Unit Of The Cic Shall Undertake Negotiation With Your Company Based On The Technical Specifications For This Project. Phoebeannr.wagan Administrativeservicesofficerv Annex"a" Priceproposalform Date: Administrativeoffice Creditinformationcorporation 6f,exchangecornerbldg.,107varufinost. Cor. Esteban St., Legaspi Village, Makati City Sir/madam: Having Examined The Request For Quotation No. Rfq No. 2024-cims(018)-npsvp-0053, Which Includes The Technical Specifications, The Receipt Of Which Is Hereby Duly Acknowledged,theundersigned,offerto,inconformitywiththesaidrequestforquotation For The Sums Stated Hereunder: Qty Uom Particulars Unitcost (in Php) Bid Price In Php (inclusiveof Vat) 1.certificatesforone(1)year Organizationvalidationwildcard Ssl Commonname: *.creditinfo.gov.ph *.creditinfo.com.ph *.creditinfodev.com.ph 2.certificatesforone(1)year 1 Lot Extendedvalidationssl -a2a-test.creditinfo.com.ph -a2a.creditinfo.com.ph -online.creditinfo.com.ph -wftp.creditinfo.com.ph -ftp-test.creditinfo.com.ph -ftp.creditinfo.com.ph -online-test.creditinfo.com.ph -sftp.creditinfo.com.ph Contractduration:one(1)year Totalbidpriceinwords: Weundertake,ifourproposalisaccepted,todeliverthegoods/servicesasidentifiedinthe Technicalspecifications/termsofreferenceandinaccordancewiththedeliveryschedule. Our Quotation Includes All Taxes, Duties And/or Levies Payable And Is Valid For A Period Ofthirty (30) Calendar Days Upon Issuance Of This Document. Weunderstand Thatthecictechnicalworkinggroup Mayrequirefromusthesubmission Of Documents That Will Prove Our Legal, Financial And Technical Capability To Undertake This Project. Untilaformalcontractis Prepared And Executed, Thisproposal,together Withyourwritten Acceptance Thereof And The Notice Of Award, Shall Be Binding Upon Us. We Understand That You Are Not Bound To Accept The Lowest Or Any Proposal You May Receive. Dated This . Signatureofauthorizedrepresentative Printednameofauthorizedrepresentative Capacity/position/designation Duly Authorized To Sign Proposalfor And Onbehalfof: Annex"b" Overview complianceform Technical Specifications Procurementofexistingsslcertificates The Credit Information Corporation (cic) Is Mandated To Collect And Aggregate Borrower’s Credit Data To Establish The Credit Worthiness Of Borrowers. Organization Validationwildcardsecuresocketlayerplaysanimportantroleincollectionanddata Processing Activities Of The Cic.cic Needs The Certificates To Secure Its Connection And Keep The Data Safe. Purpose The Cic Aims To Renew The Certificate For Secure Socket Layer To Provide Encrypted Communication Between Web Browsers And Web Servers. This Will Also Secure Authentication Between Web Servers And Server As Well As Server To Server Authentication. Wildcardsecuresocketlayer(ssl)will Provideanunlimited Number Of Sub Domainson A Singlecertificate.this Will Be Used To Secureinternal Servers In Both Primary Data Center And Secondary Site. Scope Thepaidcertificatescovertosecurethefollowingcommonnamesforone(1)year. Ovwildcardsslcertificatesfor *.creditinfo.gov.ph *.creditinfo.com.ph *.creditinfodev.com.ph Evsslcertificatesfor A2a-test.creditinfo.com.ph A2a.creditinfo.com.ph Online.creditinfo.com.ph Wftp.creditinfo.com.ph Ftp-test.creditinfo.com.ph Ftp.creditinfo.com.ph Online-test.creditinfo.com.ph Sftp.creditinfo.com.ph Definitionsofterms Term Definition Securesocketlayer(ssl) Atypeofdigitalsecuritythatallows Encryptedcommunicationbetweena Website And A Web Browser. Organizationvalidation(ov) It Is A Type Of Certificate Issued By The Certificate Provider To A Purchaser If Purchasercanmeetthe Two(2)criteria:the Righttoadministrativelymanagethedomain Nameinquestion,andperhaps,the Organization’sactualexistenceasalegal Entity. Servicelevelagreement(sla) A Commitment Between A Service Provider Andaclient.particularaspectsoftheservice – Quality, Availability, Responsibilities – Are Agreedbetweentheserviceproviderandthe Serviceuser --definitionsareretrievedfromwikipedia. Dutiesandresponsibilities Serviceprovider(sp) Thesp'sresponsibilitieswithrespecttothisprojectareasfollows: The Renewal And Assistance In The Installation Of Certificates Must Be Completed Within Thirty (30) Calendar Days From The Receipt Of The Notice To Proceed (ntp). Otherwise, The Sp Shall Pay A Penalty In The Amount Of One Tenth Of One Percent (1/10 Of 1%) Of The Total Contract Price For Every Calendar Day Of Delay. Providesfreeportaltomanagethepurchasedcertificates. Providesfreesslandwebsitesecuritycheckerwithevaluationreport. Providesfreecertificateinventorytooltolocateallcertificatesoninternaland Public Networks Regardless Of Issuing Certificate Authority. Creditinformationcorporation Cic'sresponsibilitieswithrespecttothisprojectareasfollows: Grant The Sp’s Authorized Representative Access To Its Premises, Equipment And Facilitieslocatedthereintoperformitsobligations,providedthatsuchrepresentative Shallbeaccompaniedbythedulyassignedpersonnelofthecictechnicalsupport Department. Secure The Necessary Access Pass And Building Permit Required By The Building Administrator And Assumes Responsibility For The Safe Custody And Use Of The Equipment. Monitor The Provided Services And Verify If The Parameters Under The Service Level Agreement Are Met And Performed By The Sp. Issuanceofacertificateofinspectionandacceptancetothespuponsuccessful Completion Of The Testing Certifying That The Sp Conforms To All Requirements Stipulated In This Document. Pursuant To General Procurement Policy Board (gppb) Resolution No. 019-2006 Dated 06 December 2006, At The End Of Each Year, The Cic Will Conduct An Assessment Of The Quality Of Service Provided Particularly The Cost Charged By The Sp And The Range Of Services It Offers Against Other Service Providers In The Area. Conducts Assessment/evaluation Of The Sp 60 Days Before The End Of The Contract. Requirements General Items Requirements Statementof Compliance “comply” Or “notcomply” Proof/evidenceof Compliance 1.service Provider Duly Notarized Statement That The Sphasbeeninbusinessofprovidingov Wildcard Ssl For At Least Five (5) Years Priortothedeadlineforthesubmission Of Bids. Sp Should Provide Standard 8x5 Phone And Email Support Technicalrequirements Items Requirements Statement Of Compliance “comply” Or “notcomply” Proof/evidence Of Compliance 1.system Overview 1.ovwildcardsslcertificatesfor *.creditinfo.gov.ph *.creditinfo.com.ph *.creditinfodev.com.ph 2.evsslcertificatesfor A2a-test.creditinfo.com.ph A2a.creditinfo.com.ph Online.creditinfo.com.ph Wftp.creditinfo.com.ph Ftp-test.creditinfo.com.ph Ftp.creditinfo.com.ph Online-test.creditinfo.com.ph Sftp.creditinfo.com.ph Signaturealgorithmstrengthis Sha-256 2048 Bit Future Proof Ssl Certificates Issuancespeedis1-3days Universal Compatibility With All Browsers And Devices Securesbothwww.domain.com Anddomain.com(withoutthewww) Securesiteseal Unlimited Ssl Server Licensing Promotion Unlimitedreissuanceofcertificate Free Ssl And Website Security Checker With Evaluation Reports Provides Secure Authentication Between Web Browsers And Server As Well As Server To Server Authentication Freeportaltomanagepurchased Certificate Management Compatibility With Existingorganizationvalidationssl Otherdetailswillbeprovidedupon Request Scheduleofdelivery The Service Provider Shall Commence Delivery And Implementation Of The Following Services: Ovwildcardsslcertificatesfor *.creditinfo.gov.ph *.creditinfo.com.ph *.creditinfodev.com.ph Beforejanuary21,2025 Evsslcertificatesfor A2a-test.creditinfo.com.ph A2a.creditinfo.com.ph Online.creditinfo.com.ph Wftp.creditinfo.com.ph Ftp-test.creditinfo.com.ph Ftp.creditinfo.com.ph Online-test.creditinfo.com.ph Sftp.creditinfo.com.ph Within30calendardays(leadtimefor Delivery For Non-stock Items) Upon Receipt Of The Notice To Proceed. Termsofpayment Paymentshallbemadeonthefollowing: Payment Shall Be Made On A One Time Basis Subject To Submission Of Billing Statement And Other Supporting Documents By The Sp, Subject To The Issuance Of Certificate Of Satisfactory Service By Cic. The Start Of Billing Shall Be Based On The Date Of Issuance Of “certificate Of Acceptance”. Payments Shall Be Subject To The “warranty” Provisions In The Form Of Retentionmoneyinanamountequivalenttoatleastonepercent(1%)ofthe Contract Price Required In Section 62 Of R.a. 9184 And Its Irr. Contracttermination Both Parties Have The Option Or Terminate The Contract Acceptable To Both Parties Basedonthephilippinegovernmentprocurementreformactanditsimplementing Rules And Regulations, Gppb Guidelines Or Its Issuances, And Other Philippine Laws As Applicable. Pursuanttoannexiofthe2016revisedimplementingrulesandregulations,asof 15july 2022, Of The Republicactno. 9184, The Cic Reserves The Rightto Terminate The Procurement Of Existing Ssl Certificates On The Following Grounds: Terminationbydefault: Pursuanttosection68ofthe2016revisedirr,whenoutsideofforce Majeure, The Sp Fails To Deliver Or Perform Any Or All Of The Contract Deliverables Within The Period Specified In The Contract, Or Within Any Extensionthereofgrantedbythecic Pursuantto Arequestmadeby The Sp Prior To The Delay, And Such Failure Amounts To At Least Ten Percent (10%) Of The Contract Price; Pursuant To Section 68 Of The 2016 Revised Irr, The Sp, As A Result Oftheforcemajeure,is Unabletodeliverorperformanyorallofthe Contractdeliverables,amountingtoatleasttenpercent(10%)ofthe Contract Price, For A Period Of Not Less Than Sixty (60) Calendar Days Afterreceiptofnoticefromthecicstating That Thecircumstancesof Force Majeure Is Deemed To Have Ceases; Or Thespfailstoperformanyotherobligationunderthecontract. Termination For Convenience, In Whole Or In Part. If The Cic Has Determined The Existence Of Conditions That Make The Contract Implementation Economically, Financially Or Technically Impractical And/or Unnecessary,suchas,butnotlimitedto,fortuitousevent/sorchangesin Law And National Government Policies. Terminationforinsolvency. Ifthespisdeclaredbankruptorinsolventas Determined With Finality By A Court Of Competent Jurisdiction. Terminationforunlawfulacts.incaseitisdeterminedprimafaciethatthe Sp Engaged, Before Or During The Implementation Of The Contract, In Unlawful Deeds And Behaviors Relative To Contract Acquisition And Implementation. Statementofcompliance Dated This . Signatureofauthorizedrepresentative Printednameofauthorizedrepresentative Capacity/position/designation Dulyauthorized Tosigncomplianceforand Onbehalfof: Annex"c" Omnibusswornstatement Republic Of The Philippines ) City/municipality Of )s.s. Affidavit I,[nameofaffiant],oflegalage,[civilstatus],[nationality],andresidingat[address Of Affiant], After Having Been Duly Sworn In Accordance With Law, Do Hereby Depose And State That: Selectone,deletetheother: [if A Soleproprietorship:] I Am The Sole Proprietor Or Authorized Representative Of [name Of Bidder] With Office Address At [address Of Bidder]; [if A Partnership, Corporation, Cooperative, Or Joint Venture:] I Am The Duly Authorizedanddesignatedrepresentativeof[nameofbidder]withofficeaddressat [address Of Bidder]; Selectone,deletetheother: [if A Sole Proprietorship:] As The Owner And Sole Proprietor, Or Authorized Representative Of [name Of Bidder], I Have Full Power And Authority To Do, Execute And Perform Any And All Acts Necessary To Participate, Submit The Bid, And To Sign And Execute The Ensuing Contract For [name Of The Project] Of The [name Of The Procuringentity],asshownintheattacheddulynotarizedspecialpowerofattorney; [ifapartnership,corporation,cooperative,orjointventure:]iamgrantedfullpower And Authority To Do, Execute And Perform Any And Allacts Necessary To Participate, Submit The Bid, And To Sign And Execute The Ensuing Contract For [name Of The Project]ofthe[nameoftheprocuring Entity], Asshown Intheattached [statetitle Of Attached Document Showing Proof Of Authorization (e.g., Duly Notarized Secretary’s Certificate, Board/partnership Resolution, Or Special Power Of Attorney, Whichever Is Applicable;)]; [nameofbidder] Isnot“blacklisted” Orbarred From Biddingby The Government Of The Philippines Or Any Of Its Agencies, Offices, Corporations, Or Local Government Units, Foreign Government/foreign Or International Financing Institution Whose Blacklisting Rules Have Been Recognized By The Government Procurement Policy Board, By Itself Or By Relation, Membership, Association, Affiliation, Or Controlling Interestwith Another Blacklisted Person Or Entity As Defined And Providedfor In The Uniform Guidelines On Blacklisting; Each Of The Documents Submitted In Satisfaction Of The Bidding Requirements Is An Authenticcopyoftheoriginal,complete,andallstatementsandinformationprovided Therein Are True And Correct; [name Of Bidder] Is Authorizing The Head Of The Procuring Entity Or Its Duly Authorized Representative(s) To Verify All The Documents Submitted; Selectone,deletetherest: [ifasoleproprietorship:]theownerorsoleproprietorisnotrelatedtotheheadof The Procuring Entity, Procurement Agent If Engaged, Members Of The Bids And Awards Committee (bac), The Technical Working Group, And The Bac Secretariat, The Head Of The Project Management Office Or The End-user Unit, And The Project Consultants By Consanguinity Or Affinity Up To The Third Civil Degree; [if A Partnership Or Cooperative:] None Of The Officers And Members Of [name Of Bidder]isrelatedtotheheadoftheprocuringentity,procurementagentifengaged, Members Of The Bids And Awards Committee (bac), The Technical Working Group, Andthebacsecretariat,theheadoftheprojectmanagementofficeortheend-user Unit, And The Project Consultants By Consanguinity Or Affinity Up To The Third Civil Degree; [if A Corporation Or Joint Venture:] None Of The Officers, Directors, And Controlling Stockholders Of [name Of Bidder] Is Related To The Head Of The Procuring Entity, Procurementagentifengaged,membersofthebidsandawardscommittee(bac), The Technical Working Group, And The Bac Secretariat, The Head Of The Project Management Office Or The End-user Unit, And The Project Consultants By Consanguinity Or Affinity Up To The Third Civil Degree; [nameofbidder]complieswithexistinglaborlawsandstandards; [nameofbidder]isawareofandhasundertakentheresponsibilitiesasabidderin Compliance With The Philippine Bidding Documents, Which Includes: Carefullyexamineallofthebiddingdocuments; Acknowledge All Conditions, Local Or Otherwise, Affecting The Implementation Of The Contract; Made An Estimate Of The Facilities Available And Needed For The Contract To Bebid, If Any; And Inquireorsecuresupplemental/bidbulletin(s)issuedforthe[nameofthe Project]. [nameofbidder]didnotgiveorpaydirectlyorindirectly,anycommission,amount, Fee, Or Any Form Of Consideration, Pecuniary Or Otherwise, To Any Person Or Official, Personnel Or Representative Of The Government In Relation To Any Procurement Project Or Activity; And In Case Advance Payment Was Made Or Given, Failure To Perform Or Deliver Any Of The Obligations And Undertakings In The Contract Shall Be Sufficient Grounds To Constitute Criminal Liability For Swindling (estafa) Or The Commission Of Fraud With Unfaithfulness Or Abuse Of Confidence Through Misappropriating Or Converting Any Payment Received By A Person Or Entity Under An Obligation Involving The Duty To Delivercertaingoodsorservices,totheprejudiceofthepublicandthegovernment Of The Philippines Pursuant To Article 315 Of Act No. 3815 S. 1930, As Amended, Or The Revised Penal Code. Inwitnesswhereof, Ihavehereuntosetmy Hand This Day Of , 20 At , Philippines. Bidder’srepresentative/authorizedsignatory Subscribedandsworntobeforemethisdayof[month][year]at[place Of Execution], Philippines. Affiant/s Is/are Personally Known To Me And Was/were Identified By Me Through Competent Evidence Of Identity As Defined In The 2004 Rules Onnotarialpractice(a.m.no.02-8-13-sc).affiant/sexhibitedtomehis/her[inserttype Of Government Identification Card Used], With His/her Photograph And Signature Appearing Thereon, With No. . Witness My Hand And Seal This Dayof[month][year]. Nameofnotarypublic Doc. No. Page No. Book No. Seriesof. Note: “sec. 12. Competent Evidence Of Identity – The Phrase “competentevidenceof Identity”referstotheidentificationofanindividualbasedon: At Least One Current Identification Document Issued By An Official Agency Bearing The Photograph And Signature Of The Individual, Such As But Not Limited To, Passport, Driver’s License, Professional Regulations Commission Id, National Bureau Of Investigation Clearance, Police Clearance, Postal Id, Voter’sid,barangaycertification,governmentserviceandinsurancesystem (gsis) E-card, Social Security System (sss) Card, Philhealth Card, Senior Citizencard,overseasworkerswelfareadministration(owwa)id,ofwid, Seaman’s Book, Alien Certificate Of Registration/immigrant Certificate Of Registration,governmentofficeid,certificationfromthenationalcouncilfor Thewelfareofdisabledpersons(ncwdp),departmentofsocialwelfareand Development (dswd) Certification; The Board Resolution Or Secretary’s Certificate Referring To The Said Board Resolution Designating The Bidder’s Authorized Representative And Signatory Need Not Specifically Indicatetheparticularprojectwheresuchauthorityisgivenprovidedthatthesaidauthority Covers Activities By Cic.

Details: The National Institute Of Diabetes And Digestive And Kidney Diseases (niddk) Seeks Industry Partners For Clinical Research Collaborations On Therapeutics, Diagnostics Or Devices For Childhood Cholestatic Liver Diseases the National Institute Of Diabetes And Digestive And Kidney Diseases (niddk) Of The National Institutes Of Health (nih) Of The Department Of Health And Human Services (dhhs) Seeks Industry Collaborators To Provide Novel Therapeutic Agents, Diagnostic Markers, Biomarkers And Devices For Use In Nih-sponsored Multi-center Clinical Trials And Ancillary Studies In Patients With Childhood Cholestatic Liver Diseases, Including Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis (pfic), Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, Primary Sclerosing Cholangitis, And Idiopathic Neonatal Hepatitis; And The Liver Disease Related Complications Emanating From These Diseases. background: The Childhood Liver Disease Research And Education Network (children) Is A Multi-center Consortium Of 10 Clinical Sites In The United States Plus A Scientific Data Coordinating Center Funded By Niddk To Study Rare Childhood Liver Diseases That Result In Cholestasis, Including Primary Sclerosing Cholangitis, Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis (pfic), Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, And Idiopathic Neonatal Hepatitis. Five Ongoing Studies Being Conducted By Children Include: 1) A Prospective Database Of Infants With Cholestasis (probe), A Longitudinal Observational Study Starting In Infancy Which Has Enrolled 890 Infants With Biliary Atresia And 621 With Intrahepatic Cholestasis; 2) Biliary Atresia Study In Infants And Children (basic), A Longitudinal Study Of Children With Biliary Atresia Both Before And After Liver Transplant, Which Has Enrolled Over 1768 Children With Biliary Atresia 3) Longitudinal Study Of Genetic Causes Of Intrahepatic Cholestasis (logic), A Longitudinal Study Of Intrahepatic Cholestasis Diseases, Which Has Enrolled 474 Subjects With Alagille Syndrome, 572 With Alpha-1 Antitrypsin Deficiency Liver Disease, 355 With Pfic And 36 With Bile Acid Defects; 4) Longitudinal Study Of Mitochondrial Hepatopathies (mitohep) With 73 Participants; And 5) Prediction By Ultrasound Of The Risk Of Hepatic Cirrhosis In Cystic Fibrosis (push), A Study Of The Prognostic Value Of Hepatic Ultrasound On The Development Of Liver Fibrosis In Cf, Which Has Enrolled Over 770 Subjects. In Addition, Children Completed A Placebo-controlled Clinical Trial To Determine If Post-operative Corticosteroid Therapy Improves Serum Bilirubin And Survival Without Liver Transplantation In 140 Infants With Biliary Atresia Who Have Undergone The Kasai Surgery ("start"). Ancillary Studies To Evaluate The Natural History, Clinical Outcomes And Quality Of Life, Pathogenesis, Genetics And Genomics, Proteomics, Metabolomics, Lipidomics, Imaging Studies, And Determinants Of Progression And Severity Of These Cholestatic Liver Diseases Present A Variety Of Research Collaboration Opportunities. Children Is Also Interested In Conducting Clinical Trials Of Promising Therapies To Improve Clinical Outcomes For These Cholestatic Liver Diseases. Finally, Improved Diagnostics Or Screening Procedures For Biliary Atresia And Cholestasis In Infants Are Of Great Interest To Children. study Goals: The Overall Goal Of Children Is To Determine The Etiology, Genetics, Pathogenesis, Natural History, Clinical Outcomes, Complications, Predictors Of Outcomes And Optimal Therapy Of The Cholestatic Liver Diseases. Children Studies Have Enrolled And Are Following A Relatively Large And Well Characterized Population Of Children And Young Adults With These Rare Disorders. Children Is Interested In Conducting Research That Will Lead To Improved Clinical Outcomes In Children And Young Adults With These Cholestatic Liver Diseases With Industry Collaborators To: • Evaluate The Natural History, Pathogenesis, Diagnosis, Genetic Factors, Genomics, Proteomics, Metabolomics, Lipidomics, Epigenomics, Imaging Studies, And Determinants Of Progression And Severity Of Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Pfic, Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, Primary Sclerosing Cholangitis, Or Idiopathic Neonatal Hepatitis. • Explore Use Of Serum Markers For Fibrosis And Serum Markers For Disease Activity To Predict Hepatic Histology Either By Themselves Or In Combination With Other Clinical, Laboratory, Genomic, Proteomic, Metabolomic, And Lipidomic Variables • Explore The Utility Of These Serum Markers As Surrogate Markers Of Therapeutic Response In Study Subjects Participating In Treatment Trials (e.g., Start Study For Biliary Atresia) • Investigate Proprietary Drugs (such As Novel Choleretic Agents, Anti-fibrogenic Agents, Autophagy Inducers, Chloride Channel Inducers, Fat-soluble Vitamin Supplements, Bone Mineral Density Agents, Etc.), Reagents, Or Devices In Controlled Randomized Clinical Trials As Potential Diagnostics Or Therapies For Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Pfic, Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, Primary Sclerosing Cholangitis, Or Idiopathic Neonatal Hepatitis • Evaluate Novel Newborn Or Infant Screening Techniques Or Devices For Biliary Atresia Or Cholestasis. • Evaluate Noninvasive Imaging Methods For Assessing Fibrosis, Biliary Disease, And Parenchymal Pathology In These Diseases Including But Not Limited To The Use Of Elastography, Nuclear Magnetic Resonance Imaging, And Molecular Imaging. • Evaluate The Use Of Cytokine Assays For Analyses Of Serum/plasma Cytokine Levels As Markers Of Disease Activity And As Surrogate Markers Of Histologic Or Clinical Improvement In Therapeutic Trials capability Statement: Commercial Organizations Interested In Pursuing Clinical Collaborations With Niddk For Childhood Cholestatic Liver Diseases Are Required To Submit A Capability Statement To Niddk. The Capability Statements Submitted In Response To This Announcement Will Be Used To Evaluate And Select Industry Collaborators. The Capability Statement Should Not Exceed 10 (ten) Pages Of Narrative (not Including Appendices) And Should Include The Following Information: 1. A Description Of The Therapeutic, Diagnostic Or Device Proposed To Be Used In The Clinical Research Study. (note: The Proposed Therapeutic Or Device Must Have Been Tested Already In A Phase I Trial In Humans.) 2. The Specific Details Of The Methods To Be Utilized In The Investigation Of The Pharmacologic, Surgical Or Device Intervention In Patients With Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Pfic, Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, Primary Sclerosing Cholangitis, Or Idiopathic Neonatal Hepatitis, And A Clear Description Of All Important Issues Surrounding The Evaluation Of Disease Progression In These Patients. 3. A Detailed Plan Demonstrating The Ability To Provide Sufficient Quantities Of The Therapeutic, Diagnostic Or Device In A Timely Manner For The Duration Of The Study. 4. A Description Of All Laboratory Tests That Are Needed, Including Assays And Required Amount Of Specimens, To Determine Specific Biomarker Levels Along With Appropriate Methods For Performing Such Tests. 5. A Description Of Other Core Facilities And Interactions With Core Facilities That Are Needed For The Study. 6. Dosing And Pharmacokinetic Data From Human Studies For Any Novel Therapeutics. 7. Adverse Event Profile For The Proposed Therapeutic Or Device. 8. A Description Of The Practices And Procedures That Would Be Used To Assure Patient Privacy And Maintain Confidentiality Of Data Obtained From The Study. 9. (optional) Outcome Measures Of Interest To The Organization. The Specifics Of The Proposed Outcome Measures Should Include But Not Be Limited To Treatment And Evaluation Of Biliary Atresia, Alpha-one Antitrypsin Deficiency, Cystic Fibrosis Liver Disease, Alagille Syndrome, Pfic, Bile Acid Synthesis Defects, Mitochondrial Respiratory Chain And Fatty Acid Oxidation Defects, Primary Sclerosing Cholangitis, Or Idiopathic Neonatal Hepatitis. 10. Any Other Resources The Organization Proposes To Commit To The Collaboration (in Addition To The Proposed Therapeutic, Diagnostic Or Device), Which May Include Any Of The Following: Equipment, Reagents, Supplies, Access To Facilities, Personnel Or Services, And, If Appropriate, Funding (pursuant To A Cooperative Research And Development Agreement (crada) Authorized Under 15 U.s.c. § 3710a), To Help Support The Conduct Of The Clinical Study. 11. Affirmative Statements That The Organization: a. Agrees To Provide A Letter Of Cross Reference To The Drug, Biologic Or Device Master File For The Proposed Therapeutic Or Device, Which Will Be Included With Any Us Fda Filing By The Ind Or Ide Sponsor Of The Children Study; b. Agrees To Have The Proposed Therapeutic, Diagnostic Or Device Used In Children-developed Protocols Which Will Be Conducted By The Children Research Network For Which The Study Data Collection And Analysis Will Be Performed By The Children Scientific And Data Coordinating Center; c. Agrees To Assure Patient Privacy And Will Maintain Confidentiality Of Data Obtained From The Study; d. Agrees To Share All Safety Data From Other Studies Involving The Proposed Therapeutic Or Device As Well As Relevant Efficacy Data From Other Studies (updated Investigator Brochure, Etc) With The Children; e. Understands That Because The Children Network Is Supported By Niddk Funding, The Study Results Will Be Published And Therefore Agrees To The Prompt Publication Of Research Results From The Clinical Study Using The Organization's Proposed Therapeutic, Diagnostic Or Device; And f. Understands That The Clinical Study Will Be Conducted Under An Agreement With Niddk Which Must Adhere To Phs Intellectual Property Policies (see: Http://www.ott.nih.gov/policy/phspat_policy.aspx). submission: Capability Statements Received By Niddk Will Be Considered. Prospective Collaborators May Be Invited To Attend, At Their Own Expense, A Children Steering Committee Meeting To Be Held In The Baltimore-washington, Dc Area To Discuss The Information In Their Capability Statement With The Steering Committee Members. Note:no Funds Will Be Provided By Niddk To Any Organization Selected For This Clinical Research Collaboration Opportunity. submision And Inquiries: Submit Capability Statements To: noo Coordinator, National Institute Of Diabetes And Digestive And Kidney Diseases e-mail: Niddkottdip@niddk.nih.gov for Scientific Inquiries Contact: edward Doo, Md director, Liver Diseases Research Program division Of Digestive Diseases And Nutrition, Niddk 6707 Democracy Blvd., Room 6149 bethesda, Md 20892-5450 telephone: (301) 451-4524 fax: (301) 480-8300 e-mail: Dooe@niddk.nih.gov katrina Loh, Md director, Pediatric Gastrointestinal And Liver Diseases division Of Digestive Diseases And Nutrition, Niddk 6707 Democracy Blvd., Room 6148 bethesda, Md 20892-5450 telephone: (301) 827-1079 fax: (301) 480-8300 e-mail: Katrina.loh@nih.gov for Inquiries Regarding Partnering With Niddk (intellectual Property Matters And Collaboration Agreements) Contact: agnes Rooke, Jd technology Advancement Office niddk, Nih, Hhs telephone: 301-451-6072 e-mail: Agnes.rooke@nih.gov this Notice Of Opportunity Is Also Posted At: Http://techdev.niddk.nih.gov/collabs.shtml.

Details: Request For Information pursuant To Far 15.201(e) - This Is A Request For Information (rfi) Only. This Rfi Is Issued Solely For Information And Planning Purposes – It Does Not Constitute A Request For Proposal (rfp) Or A Promise To Issue An Rfp In The Future. This Request For Information Does Not Commit The Government To Contract For Any Supply Or Service Whatsoever. Further, The Government Is Not At This Time Seeking Proposals And Will Not Accept Unsolicited Proposals. Responders Are Advised That The U.s. Government Will Not Pay For Any Information Or Administrative Costs Incurred In Response To This Rfi; All Costs Associated With Responding To This Rfi Will Be Solely At The Interested Party’s Expense. Interested Parties Are Responsible For Adequately Marking Proprietary Or Competition Sensitive Information Contained In Their Response. Proprietary Information Will Be Safeguarded In Accordance With The Applicable Government Regulations. Failure To Respond To This Rfi Does Not Preclude Participation In Any Future Associated Rfp That May Be Issued. background/purpose/technical Requirements the Naval Air Warfare Center Aircraft Division (nawcad) Webster Outlying Field (wolf) Division Is Soliciting Information And Comments From Industry On Its Ability To Provide Non-developmental Or Commercial Off The Shelf (cots) Network Radio Gateways (nrg) For Integration Into Full Scale Deployable And Scalable Transit Case Systems. The Nrgs Will Function As A Voice And Data Conferencing Center For Tactical And Commercial Radios, Internet Protocol Based Systems, And Cellular Phones. responses requested Information section 1 Of The Response Shall Provide Administrative Information, And Shall Include The Following As A Minimum: organization Name, Mailing Address, Overnight Delivery Address (if Different From Mailing Address), Phone Number, Fax Number, And Name And E-mail Of Designated Point Of Contact. business Type (large Business, Small Business, Small Disadvantaged Business, 8(a)-certified Small Disadvantaged Business, Hub Zone Small Business, Woman-owned Small Business, Very Small Business, Veteran-owned Small Business, Service-disabled Veteran-owned Small Business). country Of Origin For Main Component(s) section 2 Of The Response Shall Provide Technical Information, And Shall Include The Following As A Minimum: interested Parties Shall Respond With Existing Capabilities Or Products That Meet All Or A Subset Of The Aforementioned Attributes. Reponses That Include Information Detailing Potential Tradeoffs Or Alternative Solutions Is Encouraged. respondents Should Provide A Detailed Description Of The Following Characteristics Of Their Solution In Their Submission: product Specification, Sketches, Or Listings Of Authorized Distributors Are Not To Count As Part Of The Page Count. list Of Certifications/standards/compliances (military Standards, Etc.) operation minimum And Maximum Operating And Storage Temperatures (in Fahrenheit) humidity Range In Relative Humidity (operating & Non-operating) features dimensions (height X Width X Depth) environmental Conditions ruggedization (if Any) connectors power other radio Types Supported radio Interfaces Supported licensing Structure disa Approved Products List Integrated Tracking System (aplits) Tracking Number (tn) client Interface Description input/output Interfaces fault Reporting power other Information total Quantity Of Units Sold To Date date Of Delivery Of The First Unit date Of Delivery Of Most Recent Unit basic And Extended Warranty Information time To Production if Applicable And Able, Respondents Shall Include A List Of Department Of Defense (dod), Department Of Justice (doj) Or Department Of Homeland Security (dohs) Programs Of Record That Currently Employ Their Solution. It Would Be Helpful If A Sponsor Poc For Each Program, With Email Address And Phone Number Could Be Identified. the Government Is Interested In Receiving Vendors’ Price Lists For Items They Believe Meet The Need In This Rfi. Supplying Price Data Does Not Imply A Contractual Obligation And Must Be Provided And Marked As Price Data. respondents Should Include A List Of Authorized Distributors. additional Information in Response To This Rfi, Respondents Shall Submit Written Responses, Not-to-exceed Ten (10) Pages In Length Via Electronic Mail. Product Specification, Sketches, Or Listings Of Authorized Distributors Will Not Count Toward The Page Limitation. The Government Is Interested In Identification Of Long Lead Items(s), Sub-systems(s), Or Systems(s). the Government Does Not Intend To Award A Contract On The Basis Of This Request Or To Otherwise Pay For The Information Solicited. Proprietary Information Will Be Safeguarded In Accordance With The Applicable Government Regulations. All Information Received In Response To The Rfi That Is Marked Proprietary Will Be Handled Accordingly. The Government Will Not Be Liable For Or Suffer Any Consequential Damages For Any Proprietary Information Not Properly Identified. Responses To This Rfi May Not Be Returned. Respondents May Not Be Notified Of The Result Of The Review. failure To Respond To This Rfi Does Not Preclude Participation In Any Future Associated Rfp That May Be Issued. Information Provided In No Way Binds The Government To Solicit Or Award A Contract. It Is The Potential Vendor’s Responsibility To Monitor This Site For The Release Of Any Follow-on Information. how To Respond interested Parties Are Requested To Respond To This Rfi With A Pdf Document Format. Responses Shall Be Limited To 10 Pages And Submitted Via E-mail Only To Truman.b.harris3.civ@us.navy.mil. Proprietary Information, If Any, Should Be Minimized And Must Be Clearly Marked. Responses Are Due No Later Than 24 January 2024, 10:00 A.m. Est. responses To This Rfi May Not Be Returned. Respondents May Not Be Notified Of The Result Of The Review. It Is The Potential Vendor’s Responsibility To Monitor This Site For The Release Of Any Follow-on Information.

Details: The National Institute Of Diabetes And Digestive And Kidney Diseases (niddk) Seeks Industry Partners For Clinical Research Collaborations On Therapeutics, Diagnostics Or Devices For The Liver Cirrhosis Network the National Institute Of Diabetes And Digestive And Kidney Diseases (niddk) Of The National Institutes Of Health (nih) Of The Department Of Health And Human Services (dhhs) Has Released Requests For Applications Rfa-dk-20-003 And Rfa-dk-20-004 For The Establishment Of The Liver Cirrhosis Network; And Seeks Industry Collaborators To Provide Novel Or Repurposed Therapeutic Agents, Diagnostic Markers, Biomarkers, Devices, Or Services For Use In Nih-sponsored Multi-center Clinical Trials And Ancillary Studies In Adult Patients With Advanced Liver Disease And Cirrhosis; And The Hepatic And Extrahepatic Related Complications Emanating From Cirrhosis. background: The Niddk Is Proposing The Establishment Of The Liver Cirrhosis Network Through Funding Opportunity Announcements Rfa-dk-20-003 Seeking Clinical Centers; And In Conjunction With Rfa-dk-20-004 Seeking A Single Scientific Data Coordination Center, In Order To Promote Clinical And Translational Research On Cirrhosis Of The Liver And Related Complications In Adults. cirrhosis Represents Not A Single Disease But Is Rather The Consequence And Major Serious Outcome Of Many Chronic Liver Diseases, Caused By A Wide Range Of Conditions. The Etiologies Of Cirrhosis In The United States Include Infectious Causes Such As Chronic Hepatitis B, C And D; Genetic Causes Such As Wilson Disease, Hemochromatosis And Alpha-1-antitrypsin Deficiency; Metabolic Causes Such As Nonalcoholic Steatohepatitis; Autoimmunity Such As Autoimmune Hepatitis, Primary Biliary Cholangitis And Sclerosing Cholangitis; And Toxic Causes Such As Alcohol-associated Liver Disease And Chronic Liver Injury From Medications Such As Methotrexate And Amiodarone. Cirrhosis From These Diseases Is Almost Always The Result Of Chronic Injury With Persistent Inflammation And Cell Damage That Results In Faulty Healing And Fibrosis. As Fibrosis Accumulates It Causes Distortion Of The Architecture Of Liver, Portal Hypertension And Compromise Of Liver Function. Clinical Complications Of Cirrhosis Include Symptoms Of Fatigue, Weakness, Weight Loss, Itching And Jaundice; Gastrointestinal Bleeding From Varices Or Portal Hypertensive Gastropathy, Coagulopathy, Ascites And Disturbance Of Fluid And Electrolyte Balance, Renal Dysfunction And Hepatic Encephalopathy. The Most Dreaded Complication Of Cirrhosis Is Hepatocellular Carcinoma, A Highly Fatal Cancer That Arises In 1 To 3% Of Persons With Cirrhosis Yearly. Once Cirrhosis Is Present, Treatment Of The Underlying Liver Disease Can Lessen Further Progression And Deterioration, But Does Not Eliminate All Risk Of Complications, Particularly Hepatocellular Carcinoma. mortality Due To Liver Disease Remains A Significant Public Health Burden In The United States, Currently Ranked 11th Overall And Ranking 6th In Persons Below The Age Of 65 Years. Cirrhosis Appears To Be Rising In Some Populations Such As Persons Living With Hiv Infection, Nonalcoholic Fatty Liver Disease And Cystic Fibrosis. Hepatocellular Carcinoma Incidence Is Also Rising In The United States And Is A Surrogate For The Prevalence Of Cirrhosis. treatment Of Underlying Causes Of Chronic Liver Disease Such As Antivirals For Chronic Hepatitis B And C; Therapeutic Phlebotomy For Genetic Hemochromatosis; Ursodiol For Primary Biliary Cirrhosis; Weight Loss For Nonalcoholic Steatohepatitis (nash), And Cessation Of Alcohol Consumption For Alcohol-associated Liver Disease, All Underpin The Overarching Clinical Approach To Prevent The Development Of Cirrhosis By Early Abrogation Of Ongoing Injury To The Still Noncirrhotic Liver. Neutralization Of The Liver Disease Etiology May Allow The Injured Liver To Invoke Endogenous Mechanisms To Reverse The Consequences Of Chronic Inflammation And The Accumulation Of Mild Or Even Modest Amounts Of Liver Fibrosis. However, Once Advanced Fibrosis Or Cirrhosis Has Been Established, Neutralization Of The Causes Of Liver Disease Generally Will Not Reverse Fibrosis Or Cirrhosis Completely. While The Residual Risk Of Complications May Be Decrease, This May Be Off-set By The Improvement In Survival, So That Patients With Cirrhosis And Advanced Fibrosis Will Live And Be At Risk For The Complications Longer. liver Transplantation Is Currently The Only Medically Viable Avenue For Patients With End-stage Liver Disease That Will Extend Their Longevity. On An Annual Basis, Despite Treatment Success Rates For Chronic Hepatitis C And Other Liver Diseases, The National Wait List For Liver Transplantation In The United States Remains Essentially Unchanged At Approximately 13,000 Patients. Only 8000 Liver Transplantations Are Performed Annually. However, Far, Far More Patients With End-stage Liver Disease Are Not Even Placed On Liver Transplantation Lists For A Variety Of Co-morbid Or Psychosocial Issues. given The Discrepancy Between The Need And The Availability Of Liver Organs For Patients On Liver Transplant Waiting Lists And The Even More Numerous Patients Who Are Unable To Be Considered For Listing For Liver Transplantation, There Is A Significant Need To Improve Our Understanding Of Clinical And Translational Scientific Aspects Of Liver Fibrosis And Cirrhosis. In Addition, There Is A Need For Furthering Fundamental Understanding Of Both The Underlying Pro- And Anti-fibrotic Mechanisms As Well As Risk Factors And Mechanisms That Accentuate Pro- And Anti-fibrotic Processes. study Goals: The Overall Goal Of The Liver Cirrhosis Network Is To Promote Clinical And Translational Research That Will Advance The Understanding Of Liver Fibrosis And Cirrhosis Pathophysiology; Improve Clinical Management Of Liver Cirrhosis And Complications Of Advanced Fibrosis; And To Conduct Clinical Trials To Alter Cirrhosis Liver Disease Trajectory And The Related Complications. While Specific Details Of The Protocols For The Liver Cirrhosis Network Are Yet To Be Defined And Will Be Made By Consensus By The Future Steering Committee Of The Network, It Is Expected That Sufficient Numbers Of Subjects Will Be Enrolled With Either Stable, Child Class A, Cirrhosis Or Evidence Of Advanced Fibrosis (such As Bridging Fibrosis On Liver Biopsy Or Evidence Of Advanced Disease As Assessed By Validated Non-invasive Markers) To Operationalize The Eventual Network Studies. An Attempt Will Be Considered To Enroll Subjects With All Forms Of Cirrhosis (viral, Autoimmune, Genetic, Toxic, Alcohol-associated And “cryptogenic”) And With A Diverse Range Of Demographics As Typifies Chronic Liver Disease In The United States. the Liver Cirrhosis Network Is Interested In Conducting Research That Will Lead To Improved Clinical Outcomes In Adults With Cirrhosis And Advanced Liver Disease With Industry Collaborators To: • Evaluate The Natural History, Pathogenesis, Diagnosis, Genetic Factors, Genomics, Proteomics, Metabolomics, Lipidomics, Epigenomics, Imaging Studies, And Determinants Of Progression And Severity Of Advanced Liver Disease And Cirrhosis-related Complications • Explore Use Of Serum Markers For Fibrosis And Serum Markers For Disease Activity To Predict Hepatic Histology Or Function Either By Themselves Or In Combination With Other Clinical, Laboratory, Genomic, Proteomic, Metabolomic, And Lipidomic Variables • Explore The Utility Of These Serum Markers As Surrogate Markers Of Therapeutic Response In Study Subjects Participating In Treatment Trials • Investigate Proprietary Or Repurposed Drugs (such As Statins, Anti-fibrogenic Agents, Autophagy Inducers, Chemo-preventive Agents, Nonsteroidal Anti-inflammatory Agents, Etc.), Reagents, Or Devices In Controlled Randomized Clinical Trials As Potential Diagnostics Or Therapies For Advanced Liver Disease, Cirrhosis And Cirrhosis Related Complications • Evaluate Noninvasive Imaging Methods For Assessing Fibrosis, Portal Vein Hypertension, Hepatic Function, Screening For Or Diagnosis Of Liver Cancer, And Parenchymal Pathology In Cirrhosis Liver Disease Including But Not Limited To The Use Of Elastography, Nuclear Magnetic Resonance Imaging, And Molecular Imaging. • Evaluate The Use Of Cytokine Assays For Analyses Of Serum/plasma Cytokine Levels As Markers Of Disease Activity And As Surrogate Markers Of Histologic Or Clinical Improvement In Therapeutic Trials capability Statement: Commercial Organizations Interested In Pursuing Clinical Collaborations With Niddk For Cirrhosis Liver Disease Are Required To Submit A Capability Statement To The Niddk. The Capability Statements Submitted In Response To This Announcement Will Be Used To Evaluate And Select Industry Collaborators. The Capability Statement Should Not Exceed 10 (ten) Pages Of Narrative (not Including Appendices) And Should Include The Following Information: 1. A Description Of The Therapeutic, Diagnostic Or Device Proposed To Be Used In The Clinical Research Study. (note: The Proposed Therapeutic Or Device Must Have Been Tested Already In A Phase I Trial In Humans.) 2. The Specific Details Of The Methods To Be Utilized In The Investigation Of The Pharmacologic, Surgical Or Device Intervention In Patients With Cirrhosis Liver Disease, And A Clear Description Of The Important Issues Surrounding The Evaluation Of Disease Progression In These Patients. 3. A Detailed Plan Demonstrating The Ability To Provide Sufficient Quantities Of The Therapeutic, Diagnostic Or Device Either In Total Prior To Study Initiation (preferred If Possible) Or In A Timely Manner For The Duration Of The Study. 4. A Description Of All Laboratory Tests That Are Needed And Proficiency In Conducting These Laboratory Tests, Including Assays And Required Amount Of Specimens, To Determine Specific Biomarker(s) Levels And List Potential Biomarkers, Along With Appropriate Methods For Performing Such Tests. 5. A Description Of Other Core Facilities And Interactions With Core Facilities That Are Needed For The Study. 6. Dosing, Pharmacodynamic, And Pharmacokinetic Data From Human Studies For Any Novel Therapeutics. 7. Adverse Event Profile For The Proposed Therapeutic Or Device. 8. A Description Of The Practices And Procedures That Would Be Used To Assure Patient Privacy And Maintain Confidentiality Of Data Obtained From The Study. 9. (optional) Outcome Measures Of Interest To The Organization. The Specifics Of The Proposed Outcome Measures Should Include But Not Be Limited To Treatment And Evaluation Of Cirrhosis Liver Disease Or Cirrhosis Related Complications. 10. Any Other Resources The Organization Proposes To Commit To The Collaboration (in Addition To The Proposed Therapeutic, Diagnostic Or Device), Which May Include Any Of The Following: Equipment, Reagents, Supplies, Access To Facilities, Personnel Or Services, And, If Appropriate, Funding (pursuant To A Cooperative Research And Development Agreement (crada) Authorized Under 15 U.s.c. § 3710a), To Help Support The Conduct Of The Clinical Study. 11. Affirmative Statements That The Organization: a. Agrees To Provide A Letter Of Cross Reference To The Drug, Biologic Or Device Master File For The Proposed Therapeutic Or Device, Which Will Be Included With Any Us Fda Filing By The Ind Or Ide Sponsor Of The Liver Cirrhosis Network Study; b. Agrees To Have The Proposed Therapeutic, Diagnostic Or Device Used In The Liver Cirrhosis Network-developed Protocols Which Will Be Conducted By The Liver Cirrhosis Network Research Network For Which The Study Data Collection And Analysis Will Be Performed By The Liver Cirrhosis Network Scientific And Data Coordinating Center; c. Agrees To Assure Patient Privacy And Will Maintain Confidentiality Of Data Obtained From The Study; d. Agrees To Share All Safety Data From Other Studies Involving The Proposed Therapeutic Or Device As Well As Relevant Efficacy Data From Other Studies (updated Investigator Brochure, Etc) With The Liver Cirrhosis Network; e. Understands That Because The Liver Cirrhosis Network Is Supported By Niddk Funding, The Study Results Will Be Published And Therefore Agrees To The Prompt Publication Of Research Results From The Clinical Study Using The Organization's Proposed Therapeutic, Diagnostic Or Device; f. Has Intellectual Property Rights To Provide Laboratory Test/biomarker(s), Therapeutic Or Device To Niddk For Testing And Has No Current Agreements Or Arrangements That Could Impede This Right; And f. Understands That The Clinical Study Will Be Conducted Under An Agreement With Niddk Which Must Adhere To Phs Intellectual Property Policies (see: Http://www.ott.nih.gov/policy/phspat_policy.aspx). submission: Capability Statements Received By Niddk Will Be Considered. Prospective Collaborators May Be Invited To Attend, At Their Own Expense, A Liver Cirrhosis Network Steering Committee Meeting To Be Held In The Baltimore-washington, Dc Area To Discuss The Information In Their Capability Statement With The Steering Committee Members. Note:no Funds Will Be Provided By Niddk To Any Organization Selected For This Clinical Research Collaboration Opportunity. submision And Inquiries: Submit Capability Statements To: noo Coordinator, National Institute Of Diabetes And Digestive And Kidney Diseases e-mail: Niddkottdip@niddk.nih.gov for Scientific Inquiries Contact: edward Doo, Md, director, Liver Diseases Research Program division Of Digestive Diseases And Nutrition, Niddk 6707 Democracy Blvd., Room 6149 bethesda, Md 20892-5450 telephone: (301) 451-4524 fax: (301) 480-8300 e-mail: Dooe@niddk.nih.gov for Inquiries Regarding Partnering With Niddk (intellectual Property Matters And Collaboration Agreements) Contact: agnes Rooke, Jd technology Advancement Office niddk, Nih, Hhs telephone: 301-451-6072 e-mail: Agnes.rooke@nih.gov this Notice Of Opportunity Is Also Posted At: Http://techdev.niddk.nih.gov/collabs.shtml.